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A Two-Layer Continuous-Capillary Oxygen Transport Model: Development And Application To Blood Flow Regulation In Resting Skeletal Muscle., Keith C. Afas
Electronic Thesis and Dissertation Repository
In skeletal muscle (SM), the microcirculation distributes blood flow to capillary networks to meet local oxygen (O2) demand. Experiments using intra-vital video microscopy (IVVM) have quantified blood flow and O2 supply in capillary networks, and using an O2 exchange chamber have measured local changes in blood flow believed due to O2-dependent regulation. However, IVVM is unable to simultaneously measure capillary O2 supply and SM O2 content, implying the need for theoretical models to understand how flow regulation and SM oxygenation interact. In this thesis, a novel blood-tissue O2 transport model using …
Cost-Effective Non-Destructive Testing Of Biomedical Components Fabricated Using Additive Manufacturing, Santiago Fabian Cobos
Cost-Effective Non-Destructive Testing Of Biomedical Components Fabricated Using Additive Manufacturing, Santiago Fabian Cobos
Electronic Thesis and Dissertation Repository
Biocompatible titanium-alloys can be used to fabricate patient-specific medical components using additive manufacturing (AM). These novel components have the potential to improve clinical outcomes in various medical scenarios. However, AM introduces stability and repeatability concerns, which are potential roadblocks for its widespread use in the medical sector. Micro-CT imaging for non-destructive testing (NDT) is an effective solution for post-manufacturing quality control of these components. Unfortunately, current micro-CT NDT scanners require expensive infrastructure and hardware, which translates into prohibitively expensive routine NDT. Furthermore, the limited dynamic-range of these scanners can cause severe image artifacts that may compromise the diagnostic value of …