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Full-Text Articles in Engineering

Microfabricated Platforms To Investigate Cell Mechanical Properties, Amir M. Esfahani, Grayson Minnick, Jordan Rosenbohm, Haiwei Zhai, Xiaowei Jin, Bahareh Tajvidi Safa, Justin Brooks, Ruiguo Yang Dec 2021

Microfabricated Platforms To Investigate Cell Mechanical Properties, Amir M. Esfahani, Grayson Minnick, Jordan Rosenbohm, Haiwei Zhai, Xiaowei Jin, Bahareh Tajvidi Safa, Justin Brooks, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

Mechanical stimulation has been imposed on living cells using several approaches. Most early investigations were conducted on groups of cells, utilizing techniques such as substrate deformation and flow-induced shear. To investigate the properties of cells individually, many conventional techniques were utilized, such as AFM, optical traps/optical tweezers, magnetic beads, and micropipette aspiration. In specific mechanical interrogations, microelectro- mechanical systems (MEMS) have been designed to probe single cells in different interrogation modes. To exert loads on the cells, these devices often comprise piezo-electric driven actuators that attach directly to the cell or move a structure on which cells are attached. Uniaxial …


Investigation And Statistical Modeling Of The Mechanical Properties Of Additively Manufactured Lattices, Derek G. Spear, Anthony N. Palazotto Jul 2021

Investigation And Statistical Modeling Of The Mechanical Properties Of Additively Manufactured Lattices, Derek G. Spear, Anthony N. Palazotto

Faculty Publications

This paper describes the background, test methodology, and experimental results associated with the testing and analysis of quasi-static compression testing of additively manufactured open-cell lattice structures. The study aims to examine the effect of lattice topology, cell size, cell density, and surface thickness on the mechanical properties of lattice structures. Three lattice designs were chosen, the Diamond, I-WP, and Primitive Triply Periodic Minimal Surfaces (TPMSs). Uniaxial compression tests were conducted for every combination of the three lattice designs, three cell sizes, three cell densities, and three surface thicknesses. In order to perform an efficient experiment and gain the most information …