Engineering Commons^™

Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence

Theses and Dissertations

Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …

Effects Of Inlet Conditions On Diffuser Outlet Performance, Zaccary A. Poots

UNLV Theses, Dissertations, Professional Papers, and Capstones

Building air distribution terminal system designers and system installers require accurate quantitative information on the performance of the installed system to achieve optimum efficiency and levels of human comfort. This requires field installation adjustment values from published ideal pressure loss, air distribution and sound generation installation performance. This study documents the air output performance of different installation configurations of six types of ceiling diffusers and compares the results to performance when installed according to ANSI/ASHRAE Standard 70-2006. A diffuser inlet supply plenum was designed for optimum flow and used to acquire a baseline set of data covering the six types …

Field Measurement & Verification Of Residential Duct Leakage Methods And Cfd Analysis Of Hvac Mixing Box, Uday Vadlamani

UNLV Theses, Dissertations, Professional Papers, and Capstones

The research work in this thesis is subdivided to providing the initial results of the experimental work followed by simulation work at the end. The experimental work proposes a new measurement technique for measuring total and local leakages in ducts. The experimental work in this research tries to focus effort on finding the approximate locations of leaks in the HVAC residential duct systems to direct better the effort of duct sealing. This technique can provide several advantages over existing techniques. It will eventually have a greater potential to locate leaks so that retrofitting in ducts can be focused on leaky …

The Effect Of Office Chair Backrest Design On The Body's Metabolic Response To Office Work, Stephen H. Freier

Master's Theses (2009 -)

Most office chairs have a backrest that is wider at the shoulders than at the hips. Recently, a new office chair was developed that has a backrest that is narrower at the shoulders and wider at the hips (upwardly tapered backrest). The upwardly tapered backrest should allow users to increase their ventilatory efficiency, compared to a conventional, wide backrest. This new backrest design will hypothetically allow a user to retract their scapulae, increase expansion of the chest cavity, thus allowing the lungs more space to expand. Specific measures of improved ventilatory efficiency are an increase in tidal volume (V_{t …}

Effects Of Ventilation On Human Thermal Comfort In Rooms, Ahmed F. Alfahaid

Mechanical & Aerospace Engineering Theses & Dissertations

Nowadays, the majority of people spend up to 90% of their time indoors; as a result, the maintenance of optimal indoor climate conditions has become important for their overall health and comfort. The main goal of this study is to predict numerically the flow and temperature patterns and the human thermal comfort conditions in an indoor environment using displacement ventilation.

A Computational Fluid Dynamics (CFD) code has been used to analyze thermal comfort conditions for a fullscale ventilated room. Unstructured grids have been used to discretize the numerical domain. Before undertaking a detailed investigation, the code was validated by comparing …