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Predicting Articular Cartilage Constituent Material Properties Following In Vitro Growth Using A Proteoglycan-Collagen Mixture Model, Michael Stender
Predicting Articular Cartilage Constituent Material Properties Following In Vitro Growth Using A Proteoglycan-Collagen Mixture Model, Michael Stender
Master's Theses
A polyconvex continuum-level proteoglycan Cauchy stress function was developed based on the continuum electromechanical Poisson-Boltzmann unit cell model for proteoglycan interactions. The resulting proteoglycan model was combined with a novel collagen fibril model and a ground substance matrix material to create a polyconvex constitutive finite element model of articular cartilage. The true collagen fibril modulus , and the ground substance matrix shear modulus , were varied to obtain the best fit to experimental tension, confined compression, and unconfined compression data for native explants and explants cultured in insulin-like growth factor-1 (IGF-1) and transforming growth factor-β1 (TGF-β1). Results indicate …