Engineering Commons^™

Developing Multi-Species Brain-Strain-Based Scaling Law Using Finite Element Analysis., Xingyu Liu

Electronic Thesis and Dissertation Repository

To better understand traumatic brain injury (TBI), various laboratory animal experiments have been developed. However, there lacks an effective scaling to connect animal TBI models with human brain injuries. With the help of the finite element (FE) model, brain mechanical responses such as strains can be predicted, and hence can serve as a parameter to facilitate animal to human scaling, as these tissue-level strains directly link to neuronal damage. In this thesis, first, a comprehensive comparison of brain strains between animal TBI models and human TBI cases was conducted. Then, a brain-strain-based scaling law between mouse and human was developed, …