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Response Of Endothelial Cells To Quantified Hemodynamic Shear Stress, Hamed Avari
Response Of Endothelial Cells To Quantified Hemodynamic Shear Stress, Hamed Avari
Electronic Thesis and Dissertation Repository
Cardiovascular diseases (CVDs) are the number one cause of death globally. Arterial endothelial cell (EC) dysfunction plays a key role in many of these CVDs, such as atherosclerosis. Blood flow-induced wall shear stress (WSS), among many other pathophysiological factors, is shown to significantly contribute to EC dysfunction.
The present dissertation is an in vitro investigation of quantified WSS on ECs to quantitatively analyze the EC morphometric parameters, as well as cytoskeletal remodeling.
A hemodynamic facility based on the parallel plate flow chamber (PPFC) concept. The Laser Doppler Velocimetry (LDV) method with a custom set-up was implemented to suit the needs …