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Engineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Mechanical Engineering

University of Louisville

Electronic Theses and Dissertations

Theses/Dissertations

2014

Particles--Analysis

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Numerical Investigation Of Hydrodynamic Focusing And Coulter Principle In A Microfluidic Device, Muheng Zhang Aug 2014

Numerical Investigation Of Hydrodynamic Focusing And Coulter Principle In A Microfluidic Device, Muheng Zhang

Electronic Theses and Dissertations

Particle information such as particle size and amount is significant to many fields such as chemical engineering, biological research, medical analysis, and environment detection. Microfluidic Coulter counter is suitable for this task because it can get fast and accurate analysis. However, the fundamental principle and several design strategies details are still needed to be analyzed and modeled in order to improve its performance. This dissertation focused on several challenges from the numerical simulation aspects. First one is the analysis for the hydrodynamic focusing in microfluidic Coulter Counter. In recent years, many microfluidic Coulter Counter designs have utilized a technique termed …