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The Passive Load-Bearing Capacity Of The Human Lumbar Spine In The Neutral Standing Posture, Shaun B. Jeffs
The Passive Load-Bearing Capacity Of The Human Lumbar Spine In The Neutral Standing Posture, Shaun B. Jeffs
Theses and Dissertations
The human lumbar spine has been shown to support compressive loads of 1000 N in standing and walking, and up to many thousands of Newtons in strenuous activities such as lifting. The literature presents a number of biomechanical models that seek to replicate the load-carrying capacity of the spine while adhering to physiological constraints. While many of these models provide invaluable insights into the mechanisms governing spinal stability, there is a nearly universal disregard for the magnitude of the muscle forces required in the neutral standing posture. In compliance with constraints on metabolic cost and muscle fatigue, muscle activations in …
A Proteolytic Process To Simulate The Mechanics Of Disc Dengeration In Bovine Cadaveric Tissue, Timothy A. Bishop
A Proteolytic Process To Simulate The Mechanics Of Disc Dengeration In Bovine Cadaveric Tissue, Timothy A. Bishop
Theses and Dissertations
Purpose. The present work hypothesized that proteolytic dissolution of intervertebral discs could induce biomechanical change comparable to the change observed in natural disc degeneration. A method to do such could be utilized for in vitro research where intersample differences in geometry and chemical makeup render it difficult to compare and aggregate results into generalized conclusions.
Methods. Forty-one bovine coccygeal intervertebral discs were isolated with individual functional spinal units. Samples were loaded in three modes: compression/tension, flexion/extension, and axial rotation. The anulus fibrosus of each disc was injected with 200µl trypsin or fetal bovine serum (control) and incubated for an allotted …