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Hemocompatibility Comparison Of Biomedical Grade Polymers Using Rabbit Thrombogenicity Model For Preparing Nonthrombogenic Nitric Oxide Releasing Surfaces, Hitesh Handa, Terry C. Major, Elizabeth Brisbois, Kagya Amoako, Mark E. Meyerhoff, Robert E. Bartlett
Hemocompatibility Comparison Of Biomedical Grade Polymers Using Rabbit Thrombogenicity Model For Preparing Nonthrombogenic Nitric Oxide Releasing Surfaces, Hitesh Handa, Terry C. Major, Elizabeth Brisbois, Kagya Amoako, Mark E. Meyerhoff, Robert E. Bartlett
Mechanical and Industrial Engineering Faculty Publications
Nitric oxide (NO) is an endogenous vasodilator as well as natural inhibitor of platelet adhesion/ activation. Nitric oxide releasing (NOrel) materials can be prepared by doping an NO donor species, such as diazeniumdiolated dibutylhexanediamine (DBHD/N2O2), within a polymer coating. The inherent hemocompatibility properties of the base polymer can also influence the efficiency of such NO release coatings. In this study, four biomedical grade polymers were evaluated in a 4 h rabbit model of thrombogenicity for their effects on extracorporeal circuit thrombus formation and circulating platelet count. At the end of 4 h, Elast-Eon E2As was found to preserve 58% of …
Nitric Oxide-Generating Silicone As A Blood-Contacting Biomaterial, Kagya Amoako
Nitric Oxide-Generating Silicone As A Blood-Contacting Biomaterial, Kagya Amoako
Mechanical and Industrial Engineering Faculty Publications
Coagulation upon blood-contacting biomaterials remains a problem for short and long-term clinical applications. This study examined the ability of copper(II)-doped silicone surfaces to generate nitric oxide (NO) and locally inhibit coagulation. Silicone was doped with 3-micron copper (Cu(0)) particles yielding 3 to 10 weight percent (wt%) Cu in 70-μm thick Cu/Silicone polymeric matrix composites (Cu/Si PMCs). At 3, 5, 8 and 10 wt% Cu doping, the surface expression of Cu was 12.1 ± 2.8%, 19.7 ± 5.4%, 29.0 ± 3.8%, and 33.8 ± 6.5% respectively. After oxidizing Cu(0) to Cu(II) by spontaneous corrosion, NO flux, JNO (mol*cm−2*min−1), as measured by …