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Full-Text Articles in Engineering
The Hemocompatibility Of A Nitric Oxide Generating Polymer That Catalyzes S-Nitrosothiol Decomposition In An Extracorporeal Circulation Model, Terry C. Major, David O. Brant, Charles P. Burney, Kagya Amoako, Gail M. Annich, Mark E. Meyerhoff, Hitesh Handa, Robert E. Bartlett
The Hemocompatibility Of A Nitric Oxide Generating Polymer That Catalyzes S-Nitrosothiol Decomposition In An Extracorporeal Circulation Model, Terry C. Major, David O. Brant, Charles P. Burney, Kagya Amoako, Gail M. Annich, Mark E. Meyerhoff, Hitesh Handa, Robert E. Bartlett
Mechanical and Industrial Engineering Faculty Publications
Nitric oxide (NO) generating (NOGen) materials have been shown previously to create localized increases in NO concentration by the catalytic decomposition of blood S-nitrosothiols (RSNO) via copper (Cu)-containing polymer coatings and may improve extracorporeal circulation (ECC) hemocompatibility. In this work, a NOGen polymeric coating composed of a Cuo-nanoparticle (80 nm)-containing hydrophilic polyurethane (SP-60D-60) combined with the intravenous infusion of an RSNO, S- nitroso-N-acetylpenicillamine (SNAP), is evaluated in a 4 h rabbit thrombogenicity model and the anti-thrombotic mechanism is investigated. Polymer films containing 10 wt.% Cuo-nanoparticles coated on the inner walls of ECC circuits are employed concomitantly with systemic SNAP administration …
Computational Models Of Chemical Systems Inspired By Braess’ Paradox, Dante Lepore, Carl Barratt, Pauline Schwartz
Computational Models Of Chemical Systems Inspired By Braess’ Paradox, Dante Lepore, Carl Barratt, Pauline Schwartz
Chemistry and Chemical Engineering Faculty Publications
Systems chemistry is a new discipline which investigates the interactions within a network of chemical reactions. We have studied several computational models of chemical systems inspired by mathematical paradoxes and have found that even simple systems may behave in a counterintuitive, non-linear manner depending upon various conditions. In the present study, we modeled a set of reactions inspired by one such paradox, Braess’ paradox, an interesting phenomenon whereby the introduction of additional capacity (e.g. pathways) in some simple network systems can lead to an unexpected reduction in the overall flow rate of “traffic” through the system. We devised several chemical …
Nitric Oxide-Generating Silicone As A Blood-Contacting Biomaterial, Kagya Amoako
Nitric Oxide-Generating Silicone As A Blood-Contacting Biomaterial, Kagya Amoako
Mechanical and Industrial Engineering Faculty Publications
Coagulation upon blood-contacting biomaterials remains a problem for short and long-term clinical applications. This study examined the ability of copper(II)-doped silicone surfaces to generate nitric oxide (NO) and locally inhibit coagulation. Silicone was doped with 3-micron copper (Cu(0)) particles yielding 3 to 10 weight percent (wt%) Cu in 70-μm thick Cu/Silicone polymeric matrix composites (Cu/Si PMCs). At 3, 5, 8 and 10 wt% Cu doping, the surface expression of Cu was 12.1 ± 2.8%, 19.7 ± 5.4%, 29.0 ± 3.8%, and 33.8 ± 6.5% respectively. After oxidizing Cu(0) to Cu(II) by spontaneous corrosion, NO flux, JNO (mol*cm−2*min−1), as measured by …