Engineering Commons^™

Modeling And Control Of Nanoparticle Bloodstream Concentration For Cancer Therapies, Scarlett S. Bracey

Doctoral Dissertations

Currently, the most commonly used treatments for cancerous tumors (chemotherapy, radiation, etc.) have almost no method of monitoring the administration of the treatment for adverse effects in real time. Without any real time feedback or control, treatment becomes a "guess and check" method with no way of predicting the effects of the drugs based on the actual bioavailability to the patient's body. One particular drug may be effective for one patient, yet provide no benefit to another. Doctors and scientists do not routinely attempt to quantifiably explain this discrepancy. In this work, mathematical modeling and analysis techniques are joined together …

Bi- And Multi Level Game Theoretic Approaches In Mechanical Design, Ehsan Ghotbi

Theses and Dissertations

This dissertation presents a game theoretic approach to solve bi and multi-level optimization problems arising in mechanical design. Toward this end, Stackelberg (leader-follower), Nash, as well as cooperative game formulations are considered. To solve these problems numerically, a sensitivity based approach is developed in this dissertation. Although game theoretic methods have been used by several authors for solving multi-objective problems, numerical methods and the applications of extensive games to engineering design problems are very limited. This dissertation tries to fill this gap by developing the possible scenarios for multi-objective problems and develops new numerical approaches for solving them.

This dissertation …