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Oxidized Phospholipids Regulation Of The Monocyte Recruitment Parthway In Human Aortic Endothelial Cells, Piao Jian Tan
Oxidized Phospholipids Regulation Of The Monocyte Recruitment Parthway In Human Aortic Endothelial Cells, Piao Jian Tan
Masters Theses
Low-density lipoprotein particles in blood plasma invade the endothelium and become oxidized, creating risk of CHD associated with atherosclerosis, the main underlying condition in coronary heart disease. Oxidation products of the phospholipid 1-palmitoyl- 2-arachidonoyl-sn-glycerol-3-phosphatidylcholine (PAPC) are bioactive components of minimally oxidized LDL that stimulate endothelial cells that line the artery, leading to monocyte binding and atherosclerosis. It is hypothesized that the regulation of the monocyte recruitment pathway by these oxidized phospholipids is mediated by the binding of OxPAPC to one or more mediating proteins. Human recombinant VEGFR2, GRP78, and EP2bind to OxPNB, a biotinylated analog of OxPAPC, demonstrated using Western …