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Towards Completely Automated Glycan Synthesis, Matteo Panza
Towards Completely Automated Glycan Synthesis, Matteo Panza
Dissertations
Carbohydrates are ubiquitous both in nature as biologically active compounds and in medicine as pharmaceuticals. Although there has been continued interest in the synthesis of carbohydrates, chemical methods require specialized knowledge and hence remain cumbersome. The need for development of rapid, efficient and operationally simple procedures has come to the fore. This dissertation focuses on the development of a fully automated platform that will enable both experts and non-specialists to perform the synthesis of glycans. Existing automated methods for the synthesis of oligosaccharides are highly sophisticated, operationally complex, and require significant user know-how. By contrast, high performance liquid chromatography (HPLC) …
Ionic Liquids As Additives For Biodegradable Polyactic Acid, Ku-Il Park
Ionic Liquids As Additives For Biodegradable Polyactic Acid, Ku-Il Park
Dissertations
In this study, two ionic liquids (IL) with different anions (decanoate, tetrafluoroborate) but with the same phosphonium based cation were evaluated as potential plasticizers and lubricants for polylactic acid (PLA) and also for their effects on its hydrolytic and thermal degradation. Both ILs at 5wt% were well dispersible and partly miscible with PLA as evidenced by scanning electron microscopy/energy dispersive x-ray scattering, SEMIEDX, and glass transition temperature, Tg, characterization, as well as from solubility parameters calculations.
The effects of the IL containing a decanoate anion were more pronounced on lubrication and degradation as evidenced by reduced melt viscosities …