Engineering Commons^™

Surface-Enhanced Raman Spectroscopy-Based Biomarker Detection For B-Cell Malignancies, Nathan Israelsen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

B-cells are responsible for the production of antibodies and the recognition of dangerous pathogens. When B-cells become cancerous, they no longer perform these vital functions. This reduced B-cell activity results in greater susceptibility to opportunistic infections and increasing health risks. To effectively care for different cancer subtypes, targeted diagnosis and treatment is required. To determine the specific B-cell cancer type, up to twenty different cancer biomarkers on the cell surface need to be detected at the same time. Traditional methods are not capable of detecting such a large number of biomarkers simultaneously. This paper presents the design of a system …