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Towards Quality By Design (Qbd) Of Pharmaceutical Oral Films Loaded With Poorly Watersoluble Drugs, Eylul Cetindag
Towards Quality By Design (Qbd) Of Pharmaceutical Oral Films Loaded With Poorly Watersoluble Drugs, Eylul Cetindag
Dissertations
Oral films are an emerging drug delivery dosage form with numerous advantages such as ease of handling, the possibility to circumvent the first-pass metabolism, better patient compliance, capability for continuous manufacturing, and as a platform for personalized medicine. As films are different from other final dosages by their dimensions and their matrix form, further research is required to better understand the impact of excipient and drug on product performance to assure a consistent and good quality product. Therefore, this dissertation aims to contribute towards the processability and manufacturability of films by examining the impact of the materials and processes. First, …
Synthesis And Characterization Of Novel Boron-Based Nanostructures And Composites, Rajen B. Patel
Synthesis And Characterization Of Novel Boron-Based Nanostructures And Composites, Rajen B. Patel
Dissertations
A number of nanomaterials have been synthesized by using a method that has been previously utilized to make pure boron nanostructures through the addition of different reactant gases to the process. This method was pioneered by Iqbal-Liu and will be referred to as the IL method in this dissertation. The IL method successfully created boron nanowires, boron nanoflakes, and boron nanotubes. In this dissertation, by adding methane, hydrogen sulfide, and ammonia to the process, an entire family of nanomaterials is prepared. These include nanowires, nano-heterostructures, and thin nanoplatelets of a variety of elemental compositions. These materials can be integrated with …