Engineering Commons^™

Quantitative Measurement Of Cerebral Hemodynamics During Activation Of Auditory Cortex With Single- And Multi-Distance Near Infrared Spectroscopy, Penaz Parveen Sultana Mohammad

USF Tampa Graduate Theses and Dissertations

Functional Near Infrared Spectroscopy (fNIRS) is a safe, low-cost, non-invasive opti-cal technique to monitor focal changes in brain activity using neurovascular coupling and measurements of local tissue oxygenation, i.e., changes in concentrations of oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR)[42]. This thesis utilizes two fNIRS approaches to measure hemodynamic changes associated with functional stimulation of the human auditory cortex. The first approach, single-distance continuous wave NIRS (CW-NIRS) utilizes relatively simple instrumentation and the Modified-Beer Lambert (MBL) law to estimate activation induced changes in tissue oxygenation (∆CHbO and ∆CHbR)[17]. The second more complex approach, frequency domain NIRS (FD-NIRS), employs a photon …