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Signal-To-Noise Measurements And Particle Focusing In Liquid-Core Waveguides, Michael A. Olson
Signal-To-Noise Measurements And Particle Focusing In Liquid-Core Waveguides, Michael A. Olson
Theses and Dissertations
This thesis presents an analysis of the signal-to-noise ratio in liquid core anti-resonant reflecting optical waveguides (ARROWs) and the application of hydrodynamic focusing to the waveguides. These concepts are presented as a method to improve the detection capabilities of the ARROW platform. The improvements are specifically targeted at achieving single molecule detection (SMD) with the devices. To analyze the SNR of the waveguides a test platform was designed and fabricated. This test platform was then used to examine relationship between the SNR and the location of the excitation region. It was determined that the excitation region should be moved closer …