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A Computationally-Efficient Bound For The Variance Of Measuring The Orientation Of Single Molecules, Tingting Wu, Tianben Ding, Hesam Mazidi, Oumeng Zhang, Matthew D. Lew
A Computationally-Efficient Bound For The Variance Of Measuring The Orientation Of Single Molecules, Tingting Wu, Tianben Ding, Hesam Mazidi, Oumeng Zhang, Matthew D. Lew
Electrical & Systems Engineering Publications and Presentations
Modulating the polarization of excitation light, resolving the polarization of emitted fluorescence, and point spread function (PSF) engineering have been widely leveraged for measuring the orientation of single molecules. Typically, the performance of these techniques is optimized and quantified using the Cramér-Rao bound (CRB), which describes the best possible measurement variance of an unbiased estimator. However, CRB is a local measure and requires exhaustive sampling across the measurement space to fully characterize measurement precision. We develop a global variance upper bound (VUB) for fast quantification and comparison of orientation measurement techniques. Our VUB tightly bounds the diagonal elements of the …
Bio-Inspired Multi-Spectral And Polarization Imaging Sensors For Image-Guided Surgery, Nimrod Missael Garcia
Bio-Inspired Multi-Spectral And Polarization Imaging Sensors For Image-Guided Surgery, Nimrod Missael Garcia
McKelvey School of Engineering Theses & Dissertations
Image-guided surgery (IGS) can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky, costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities to distinguish cancerous from healthy tissue. In my thesis, I have addressed these challenges in IGC by mimicking the visual systems of several animals to construct low power, compact and highly sensitive multi-spectral and color-polarization sensors. I …
High-Resolution Low-Noise Polarization Imaging Sensor For Astronomical Applications, Radoslav Marinov
High-Resolution Low-Noise Polarization Imaging Sensor For Astronomical Applications, Radoslav Marinov
All Theses and Dissertations (ETDs)
Polarization imaging is useful to the field of astronomy because the polarization state caused by reflections, scattering events, and magnetic fields can be used to infer properties such as shape and index of refraction about celestial bodies. This work presents a low-noise high-resolution polarization imaging sensor consisting of a CCD imager overlaid with a nanowire linear polarizer filter array of four different orientations: 0°, 45°, 90°, and 135°) matched to the pixel pitch. Fabrication details and experimental setup for characterization are discussed. The performance of the sensor is assessed over a range of polarization states, light intensities, wavelengths, and incident …