Engineering Commons^™

Cell Bioprinting: A Novel Approach For Alpha Cell To Beta Cell Transdifferentiation, Atzimba Casas

Open Access Theses & Dissertations

Diabetes is a chronic disease that occurs in the body when the pancreas fails to either produce insulin (TID) or does not effectively use the insulin produced (TIID) and poses further health complications as well as an insurmountable economic impact.[1] Type I diabetes is an autoimmune disease characterized by a deficient amount of insulin production on account of the body’s immune system destroying its own β-cells.[2] Current diabetes treatment methods include the administration of insulin via injections or islet transplantation therapy. However, although both are viable options, they come with limitations that make the managing of this disease difficult. It …

A Cellulose-Based Biological Sensor For The Quantitative Determination Of Glucose And Glycated Hemoglobin (Hba1c), Gilberto Henao-Pabon

Open Access Theses & Dissertations

ABSTRACT

Importance: Diabetes is a common world-wide disease characterized by insulin resistance and as result there is an increased risk of cardiovascular disease and other metabolic abnormalities, that contribute to irreversible end-organ damage. The cause of diabetes is multifactorial and includes genetic, inflammatory and environmental factors plus lifestyle issues. Because in diabetes there are high levels of glucose and glycated hemoglobin, these molecules are used in clinical settings for the acute and chronic management of diabetic patients.

Objectives: a. To design and build an electrochemical biological sensor using the enzyme Glucose Oxidase (GOX) to detect glucose in biological fluids.

b. …

Determination Of The Dynamic Behavior Of Subjects With Diabetic Neuropathy, Luis G. Sagarnaga Lopez

Open Access Theses & Dissertations

The diabetic foot is one of the most feared complications of diabetes [3]. Causes of a diabetic foot come from many disorders including diabetic neuropathy, peripheral vascular disease, charcot's neuropathy, foot ulceration, and limb amputation [4]. Statistics have revealed that 8.3 percent of population in the U.S. is affected by diabetes in 2010, i.e., 25.8 million people. About 60 percent to 70 percent of people with diabetes have mild to severe forms of nervous system damage [13]. There is an enormous impact on the physical and mental health of patients who suffer from diabetes.

This research was to determine the …

An Investigation Into The Effect Of Blood Glucose Level Changes On Lf/Hf Parameter Of Hrv Signal In Non-Diabetic And Diabetic Individuals, Reza M. Amanipour

Open Access Theses & Dissertations

The analysis of time duration between consecutive R waves of electrocardiogram (ECG) is a standard method to evaluate the variations in heart rate. The physiological literature reveals that blood glucose levels modulate the autonomic nervous system (ANS) activity and heart rate variability (HRV) is representative of the cardiovascular autonomic function. In the research, an investigation was carried out to investigate the relationship between HRV signal measures derived from ECG and arterial blood glucose changes in five non-diabetic and five diabetic individuals during normoglycemic and mildly hyperglycemic conditions. A CleveLabs BioCapture wireless device was used to acquire ECG signals from ten …