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Effect Of Patient Specific Blood Biomarkers On Nanoparticle - Cell Interactions, Veronica Gabriela Contreras
Effect Of Patient Specific Blood Biomarkers On Nanoparticle - Cell Interactions, Veronica Gabriela Contreras
Open Access Theses & Dissertations
Nanoparticles are currently known to be a promising material class for bio-applications in drug delivery and vaccine development. Using gold nanoparticles of varied sizes, in this case 45 and 100 nanometers as a model nanomaterial system, we investigated how patients' blood physiology and chemistry (such as solute, protein, lipid levels) affect the biological response to bionanomaterials. When nanoparticles are injected into the body, biomolecules in the blood adsorb to the nanoparticle's surface to form a biomolecular corona that is specific to the patient's unique blood composition. This biomolecular corona is important because it affects the in vivo fate and biodistribution …
Formulation Strategies To Enhance Solubility And Permeability Of Small Molecules For Drug Delivery Applications, Pradeep Kumar Bolla
Formulation Strategies To Enhance Solubility And Permeability Of Small Molecules For Drug Delivery Applications, Pradeep Kumar Bolla
Open Access Theses & Dissertations
All the new chemical entities/drug molecules intended for therapeutic use must be administered using an appropriate delivery system/dosage form to achieve maximum bioavailability. However, designing a drug delivery system is complex as several factors such as lipophilicity, molecular mass, crystallinity, ionic charge, polymorphic forms and hydrogen bonding) affect the solubility and permeability of these molecules. Biopharmaceutics drug classification system (BCS) categorizes the existing drugs into four classes based on the aqueous solubility and membrane permeability and it is reported that >70% of the drugs are poorly soluble and belong to BCS class II and BCS class IV. Several physical, chemical …