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Applications Of The Guided-Mode Resonance Sensor In Multiparametric, Transmissive, And Picomolar Regimes, Joseph Anthony Buchanan-Vega

Electrical Engineering Dissertations

Guided-mode resonance (GMR) sensors are developed and implemented for multiparametric label-free sensing, transmission sensing, enhanced reflection sensing, and low analyte concentration sensing; these are the topics presented in this work. The complete biosensor – capable of label-free multiparametric data collection – is designed, fabricated, and implemented. Multiparametric data collection has previously been relegated to one variable on the sensor surface and one bulk media variable. We use a lookup table and the novel application of an inversion algorithm to simultaneously determine two variables on the sensor surface and one bulk media variable. Multiparametric data sets are required to monitor multiple …