Engineering Commons^™

Genetic Algorithm Optimization Of Experiment Design For Targeted Uncertainty Reduction, Alexander Amedeo Depillis

Masters Theses

Nuclear cross sections are a set of parameters that capture probability information about various nuclear reactions. Nuclear cross section data must be experimentally measured, and this results in simulations with nuclear data-induced uncertainties on simulation outputs. This nuclear data-induced uncertainty on most parameters of interest can be reduced by adjusting the nuclear data based on the results from an experiment. Integral nuclear experiments are experiments where the results are related to many different cross sections. Nuclear data may be adjusted to have less uncertainty by adjusting them to match the results obtained from integral experiments. Different integral experiments will adjust …

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Optimal Communication Structures For Concurrent Computing, Andrii Berdnikov

Doctoral Dissertations

This research focuses on communicative solvers that run concurrently and exchange information to improve performance. This “team of solvers” enables individual algorithms to communicate information regarding their progress and intermediate solutions, and allows them to synchronize memory structures with more “successful” counterparts. The result is that fewer nodes spend computational resources on “struggling” processes. The research is focused on optimization of communication structures that maximize algorithmic efficiency using the theoretical framework of Markov chains. Existing research addressing communication between the cooperative solvers on parallel systems lacks generality: Most studies consider a limited number of communication topologies and strategies, while the …

Achieving High Reliability And Efficiency In Maintaining Large-Scale Storage Systems Through Optimal Resource Provisioning And Data Placement, Lipeng Wan

Doctoral Dissertations

With the explosive increase in the amount of data being generated by various applications, large-scale distributed and parallel storage systems have become common data storage solutions and been widely deployed and utilized in both industry and academia. While these high performance storage systems significantly accelerate the data storage and retrieval, they also bring some critical issues in system maintenance and management. In this dissertation, I propose three methodologies to address three of these critical issues.

First, I develop an optimal resource management and spare provisioning model to minimize the impact brought by component failures and ensure a highly operational experience …