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Evaluating Chemical Toxicity: A Novel Behavioral Assay Using Daphnia, Maya A. Zein

Wayne State University Dissertations

Pharmaceuticals, and personal care products (PPCPs), and other emerging contaminants, such as pesticides, are increasingly being detected in the environment. Important sources of these contaminants are waste water treatment plants and agriculture. Many of these contaminants are biologically active at low concentrations, and may impair physiological processes in exposed organisms, alter reproductive, endocrine or immune system function, and ultimately affect fitness and survival. These chemicals are often found in the environment as complex mixtures, and this complicates their evaluation of their toxicity. There is a need for high-throughput assays to rapidly assess the toxicity of these emerging contaminants. A behavioral …