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Metabolomics, Genomics And Transcriptomics Unravel Fluoroalkane Metabolism In Pseudomonas Sp. Strain 273., Yongchao Xie

Doctoral Dissertations

Fluorinated organics have been developed and produced for various applications in the industrial, military, medical and agrochemical fields; they are now emerging as persistent organic pollutants with demonstrated adverse health impacts on mammals, including humans. The high bond dissociation energy of C-F bond hinders microbial degradation and defluorination. The present work demonstrates Pseudomonas sp. strain 273 can utilize the 1-fluoroalkanes (C₇ to C₁₀ and C₁₄) and 1,10-difluorodecane (DFD) as the sole carbon source in the presence of oxygen. In this study, fluorine mass balance analysis determined that the majority (> 90%) of the fluorine from the …