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Formulation Development Of A Polymer-Drug Matrix With A Controlled Release Profile For The Treatment Of Glaucoma, Eric W. Tsoi
Formulation Development Of A Polymer-Drug Matrix With A Controlled Release Profile For The Treatment Of Glaucoma, Eric W. Tsoi
Master's Theses
Glaucoma is the leading cause of blindness in the United States accounting for 9-12% of all cases of blindness. Currently, the front line treatment for glaucoma are prostaglandins that may have to be taken up to several times a day. Even with proper treatment, roughly 11% of the patients using the treatment are non-compliant and lose their vision. In this project, ForSight Laboratories has developed a pharmaceutical drug delivering implant with the capability of sustaining long-term release of a prostaglandin as a new way to treat the condition. This project reports the product development of a polymer drug matrix with …
Optimization Of Polymer Separation By Gradient Polymer Elution Chromatography, Gideon R. Liem, Linda Nien-Hwa Wang
Optimization Of Polymer Separation By Gradient Polymer Elution Chromatography, Gideon R. Liem, Linda Nien-Hwa Wang
The Summer Undergraduate Research Fellowship (SURF) Symposium
High Performance Liquid Chromatography (HPLC) has been a versatile separation method for polymers for many years. Analysis of different polymers by HPLC is typically done by utilizing the differential solubility of the polymers by mixing a good solvent and an anti-solvent in various compositions. This method is called Gradient Polymer Elution Chromatography (GPEC). While GPEC has been used extensively, it commonly uses a linear gradient to separate components. Linear solvent gradients consume a lot of solvent and take a relatively long time (> 30 minutes) to complete. The goal of this study is to develop a step gradient from a …
Development Of Quantitative Ft- Ir Methods For Analyzing The Cure Kinetics Of Epoxy Resins, Sang Ha Son
Development Of Quantitative Ft- Ir Methods For Analyzing The Cure Kinetics Of Epoxy Resins, Sang Ha Son
Open Access Dissertations
Epoxy thermosets are important engineering materials with applications in coating, adhesives, packaging and as structural components in a variety of advanced engineering products. The ultimate performance of polymer critically depends upon the details of the cure chemistry used to produce the thermoset. In order to better understand and monitor the cure chemistry, quantitative analysis of the FT-IR response has been developed for describing the epoxy-amine curing reaction as well as monitoring the hydrogen bonding that occurs in these systems The FT-IR analysis includes (i) quantitative deconvolution of complex peaks into individual spectral contributions, (ii) peak identification via DFT analysis and …