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Effects Of Operating And Geometric Variables On Hydrodynamics And Tablet Dissolution In Standard And Modified Dissolution Testing Apparatuses 2, Yimin Wang
Dissertations
Dissolution testing is routinely conducted in the pharmaceutical industry to provide critical in vitro drug release information for quality control purposes, and especially to assess batch-to-batch consistency of solid oral dosage forms such as tablets. Among the different types of apparatuses listed in the United States Pharmacopoeia (USP), the most commonly used dissolution system for solid dosage forms is the USP Dissolution Testing Apparatus 2, consisting of an unbaffled, hemispherical-bottomed vessel equipped with a 2-blade radial impeller.
Despite its extensive use in industry and a large body of work, some key aspects of the hydrodynamics of Apparatus 2 have received …
Deagglomeration And Mixing Via The Rapid Expansion Of High Pressure And Supercritical Suspensions, Daniel To
Deagglomeration And Mixing Via The Rapid Expansion Of High Pressure And Supercritical Suspensions, Daniel To
Dissertations
Nano-materials are the focus of many research activities due to the desirable properties imparted from their small grain size and high interfacial surface area. However, these materials are highly cohesive powders in the dry state and typically form large agglomerates, leading to a diminished surface area or even grain growth, which minimizes the effectiveness of these nanomaterials. This dissertation addresses the issue of mixing nanopowders constituents by deagglomerating them and achieving simultaneous mixing so that even after inevitable reagglomeration, the effectiveness of large interfacial surface area may be preserved.
Nano-particle mixtures were prepared using the environmentally benign dry mixing methods …