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Full-Text Articles in Engineering
Computational Modeling Of Biochemical Systems Using Cellular Automata, Advait Apte
Computational Modeling Of Biochemical Systems Using Cellular Automata, Advait Apte
Theses and Dissertations
Biological systems exhibit complex behaviors through coordinated responses of individual biological components. With the advent of genome-scale techniques, one focus has been to develop methods to model interactions between components to accurately describe intact system function. Mathematical modeling techniques such as constraint-based modeling, agent-based modeling, cellular automata (CA) modeling and differential equation modeling are employed as computational tools to study biological phenomenon. We have shown that cellular automata simulations can be used as a computational tool for 12 predicting the dynamics of biological systems with stochastic behavior. The basic premise for the research was the observations made during a study …
Investigation Of The Mechanical Properties Of Poly (Ethylene Glycol) Diacrylate By Nanoindentation Using Atomic Force Microscopy, Zouheir Drira
Investigation Of The Mechanical Properties Of Poly (Ethylene Glycol) Diacrylate By Nanoindentation Using Atomic Force Microscopy, Zouheir Drira
Theses and Dissertations
Poly (ethylene glycol) (PEG) hydrogel based polymers are among the most widely used synthetic materials for biomedical applications. Because of their biocompatibility, and ease of fabrication, hydrogels are highly suitable for use as constructs to engineer tissues as well as for cell transplantation. A critical parameter of importance for PEG hydrogels is their mechanical properties which are highly dependent on the environmental conditions. Properties of PEG-based hydrogels can be engineered to resemble scaffolds composed of extracellular matrix molecules, which provide structural support, adhesive sites and mechanical as well as biomechanical signals to most cells. The mechanical properties of these synthetic …
Dilute Sulfuric Acid Pretreatment Of Switchgrass In Microwave Reactor For Biofuel Conversion: An Investigation Of Yields, Kinetics,, Oscar Martin
Theses and Dissertations
Lignocellulosic materials provide a raw material source for biofuel conversion and offer several advantages over fossil fuels- usage of a renewable resource, reduced greenhouse emissions, a decreased dependence on foreign oil, and stimulation of the agricultural sector. However, a primary technological challenge in converting lignocellulosic biomass into fuel is overcoming the recalcitrance of its matrix to enzymatic hydrolysis. To overcome these problems for chemical processing, naturally occurring cellulose biomass must be pretreated before it can be further processed using enzymatic hydrolysis or bioconversion. The goal of this work was to develop a model that predicts the glucose yield (pretreatment and …
Controlled Release Of Fluoride From Poly(Ethylene-Co-Vinyl Acetate) Films, Shadeed Khan
Controlled Release Of Fluoride From Poly(Ethylene-Co-Vinyl Acetate) Films, Shadeed Khan
Theses and Dissertations
The development of aesthetically unattractive white spots is a concern for patients undergoing fixed orthodontic treatment. Due to poor oral hygiene during treatment, accumulation of plaque around orthodontic brackets causes bacterial fermentation reactions producing acids that dissolve the mineral enamel. Such dissolution results in white spot formation, an early sign of dental caries. In principal, to inhibit the appearance of these spots during treatment, fluoridated elastomeric o-rings might be employed. Once placed around brackets, these o-rings should release fluoride therapeutically for at least 30 days, after which the orthodontist may replace them. At the present time, such fluoride-releasing o-rings are …
A Parallel Molecular Dynamics Program For Simulation Of Water In Ion Channels, Laxmi Mullapudi
A Parallel Molecular Dynamics Program For Simulation Of Water In Ion Channels, Laxmi Mullapudi
Theses and Dissertations
With a modest beginning from developing a model of dynamics of hard liquid spheres (Alder et al., 1957), molecular dynamics (MD) simulations have come to a point where complex biomolecules can be simulated with precision close to reality (Noskov et al., 2007). In this context, a parallel molecular dynamics program for simulation of ion channels associated with cellular membranes has been developed. The parallel MD code developed is simple, efficient, and easily coupled to other codes such as the hybrid molecular dynamics/ brownian dynamics (MD/BD) code developed for the study of protein interactions (Ying et al., 2005). The Atom Decomposition …
Binding Studies Of Epidermal Growth Factor Receptor Targeted Compounds Using Surface Plasmon Resonance, Spandana Kankanala
Binding Studies Of Epidermal Growth Factor Receptor Targeted Compounds Using Surface Plasmon Resonance, Spandana Kankanala
Theses and Dissertations
The study of binding kinetics of proteins plays an important role in understanding molecular mechanisms that drive biological processes. The binding rate constants reflect the dynamics of the system and associated biological activity measurements of the association and dissociation rate constants make it possible to compare different interactions in a standardized manner and help elucidate a mechanistic understanding of binding events. In our study, we used Surface Plasmon Resonance (SPR) technology (Biacore) to study the binding kinetics of the antibodies EGF, Cetuximab and a candidate drug P-13 with the receptor EGFR. The candidate drug P-13 was synthesized and tested on …
The Developmental Effect Of Human Embryoid Bodies (Heb) Under Dynamic Culturing Conditions Using A Perfusion Based Slow Turning Lateral Vessel (Stlv) Bioreactor, Claiborne Collier
The Developmental Effect Of Human Embryoid Bodies (Heb) Under Dynamic Culturing Conditions Using A Perfusion Based Slow Turning Lateral Vessel (Stlv) Bioreactor, Claiborne Collier
Theses and Dissertations
Human embryonic stem cells (hESCs) can provide a unique approach for novel tissue engineering applications. Previous groups have shown that hESCs can differentiate into specialized cell types through the generation of human embryoid bodies (hEBs). These multi-cellular constructs are then subjected to suspension culture for several weeks. Traditional hESC differentiation techniques have yielded non-homogeneous EBs derived in standard static cultures providing an inefficient platform for cellular viability and embryonic modeling. Here, our study aimed at systematically comparing the formation, growth, and differentiation capabilities of hESC-derived hEBs in dynamic and static suspension cultures. We used a continuous flow perfusion slow turning …