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Novel Breath Collection Techniques For Detection Of Covid-19., James Morris
Novel Breath Collection Techniques For Detection Of Covid-19., James Morris
Electronic Theses and Dissertations
Volatile Organic Compounds (VOC) generated endogenously in the human body can be used to detect diseases that induce oxidative stress and inflammation. Breath analysis has been used for the detection of diseases such as COPD, Depression, Lung Cancer and most recently COVID-19. Methods such as Exhaled Breath Condensate (EBC), Sorbent Tubes, Solid Phase Microextraction (SPME), and silicon microreactors have shown considerable capability in extracting and concentrating trace VOC’s present in human breath. Silicon microreactors functionalized with capture agents to derivatize carbonyl compounds are effective but the overall maximum flow rate of breath sample possible during analysis is low, making direct …
Characterization Of Microreactor And Analysis Of Carbonyl Compounds In Exhaled Breath., Qi Li
Characterization Of Microreactor And Analysis Of Carbonyl Compounds In Exhaled Breath., Qi Li
Electronic Theses and Dissertations
Analysis of trace volatile organic compounds at parts per billion (ppbv) to parts per trillion (pptv) level has become an important research frontier because of the applicability for environmental monitoring and noninvasive diagnosis of diseases. The methods of preconcentration for detection of trace aldehydes and ketones both in ambient air and human exhaled breath have increased considerably over the last decade. However, the majority of these methods are not efficient. In this dissertation, we have improved an innovative microreactor that is suitable for quantitative analysis of volatile carbonyl compounds (VOCs) in ambient air as well as in human exhaled breath. …