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Full-Text Articles in Engineering
A Rapid And Ultra-Sensitive Biosensing Platform Based On Tunable Dielectrophoresis For Robust Poc Applications, Yu Jiang
Doctoral Dissertations
With the ongoing pandemic, there have been increasing concerns recently regarding major public health issues such as abuse of organophosphorus compounds, pathogenic bacterial infections, and biosecurity in agricultural production. Biosensors have long been considered a kernel technology for next-generation diagnostic solutions to improve food safety and public health. Significant amounts of effort have been devoted to inventing novel sensing mechanisms, modifying their designs, improving their performance, and extending their application scopes. However, the reliability and selectivity of most biosensors still have much to be desired, which holds back the development and commercialization of biosensors, especially for on-site and point-of-care (POC) …
Microfluidic Devices Applied On Enriching Post –Translational Modified Proteins For Proteomics, Hui Xia
Microfluidic Devices Applied On Enriching Post –Translational Modified Proteins For Proteomics, Hui Xia
Doctoral Dissertations
In this work, microfluidic devices were developed for enriching post-translational modified proteins. Post-translational modifications (PTM) of proteins play essential roles in cellular physiology and disease. The identification of protein substrates and detection of modification site helps understand PTM-mediated regulation in essential biological pathways and functions in various diseases. However, PTM proteins are typically present only at trace levels, making them difficult to identify in mass spectrometry based proteomics. This work study is about the design, fabrication and testing of the microfluidic device for the enrichment of abundant amount of PTMs. Carbonylated protein is used as a representative PTM to illustrate …
Investigation Of Ethanol Dehydration In A Microscale Pervaporation Process, Sudhir Ramprasad
Investigation Of Ethanol Dehydration In A Microscale Pervaporation Process, Sudhir Ramprasad
Doctoral Dissertations
Challenges due to surface tension effects for vaporization in microchannels have restricted the implementation of conventional separation processes that involve liquid boiling in a micro-chemical system. However, membrane separations offer a feasible alternative for exploring the advantages of liquid phase separation in micro-chemical systems. The main objective of this research was to evaluate the process intensification effects in a microscale pervaporation process with experiments involving the separation of ethanol/water using a commercially available polymer dehydration membrane.
The microchannels in the microseparator were fabricated by the dry etch process at Louisiana Tech University. Microchannel depths of 20 to 120 μm, with …