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Non-Classical Nucleation Phenomena Study And Following Process Monitoring And Optimization In Solution Crystallization Process, Zhenguo Gao

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Nucleation is a crucial step in the solution crystallization process. Despite their good development, classical nucleation theory and two-step nucleation theory cannot explain all the nucleation phenomena, especially for the non-classical nucleation phenomena which include oiling out, gelation and non-monotonic nucleation. Accordingly, for the non-classical nucleation systems, the crystallization processes are seldom designed based on the nucleation monitoring and supervision. In this thesis, crystallization process optimization was conducted to study the mechanism of non-classical nucleation phenomena and in-line process monitoring technology development.

Two kinds of non-classical nucleation phenomena with non-monotonic nucleation rate and gel formation were investigated, and accordingly, two …