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Tuning The Size And Composition Of Manganese Oxide Nanoparticles Through Varying Temperature Ramp And Aging Time, Celia Martinez De La Torre, Jasmine H. Grossman, Andrey A. Bobko, Margaret F. Bennewitz
Tuning The Size And Composition Of Manganese Oxide Nanoparticles Through Varying Temperature Ramp And Aging Time, Celia Martinez De La Torre, Jasmine H. Grossman, Andrey A. Bobko, Margaret F. Bennewitz
Faculty & Staff Scholarship
Manganese oxide (MnO) nanoparticles (NPs) can serve as robust pH-sensitive contrast agents for magnetic resonance imaging (MRI) due to Mn2+ release at low pH, which generates a ~30 fold change in T1 relaxivity. Strategies to control NP size, composition, and Mn2+ dissolution rates are essential to improve diagnostic performance of pH-responsive MnO NPs. We are the first to demonstrate that MnO NP size and composition can be tuned by the temperature ramping rate and aging time used during thermal decomposition of manganese(II) acetylacetonate. Two different temperature ramping rates (10°C/min and 20°C/min) were applied to reach 300°C and NPs were aged …