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Determination Of Ibuprofen Isotherm Using Supercritical Fluid Chromatography, Loi Ho
Determination Of Ibuprofen Isotherm Using Supercritical Fluid Chromatography, Loi Ho
USF Tampa Graduate Theses and Dissertations
Chromatography is widely used to determine physiochemical properties data including adsorption isotherm. In the separation of enantiomers through sorptive processes, supercritical fluids allow efficient and green alternatives to liquid solvent based systems. The isotherm information is vital in the development of operating policies and design of preparative chromatographic or moving bed separation schemes. Determination of sorption isotherms from experimental chromatographic elution data is automated and compared with different chromatogram model. Procedures were developed and validated for separation of R- and S- ibuprofen with supercritical 〖CO〗_2 and ethanol mixture as the mobile phase over a chiral stationary phase. The isotherms for …