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Full-Text Articles in Engineering
An Approach To Sequence Dna Without Tagging, Sanjun Niu, Ravi F. Saraf
An Approach To Sequence Dna Without Tagging, Sanjun Niu, Ravi F. Saraf
Papers in Biotechnology
Microarray technology is playing an increasingly important role in biology and medicine and its application to genomics for gene expression analysis has already reached the market with a variety of commercially available instruments. In these combinatorial analysis methods, known probe single-strand DNA (ssDNA) ‘primers’ are attached in clusters of typically 100 μm × 100 μm pixels. Each pixel of the array has a slightly different sequence. On exposure to ‘unknown’ target ssDNA, the pixels with the right complementary probe ssDNA sequence convert to double-stranded DNA (dsDNA) by a hybridization reaction. To transduct the conversion of the pixel to dsDNA, the …
Poly (1-Trimethysilyl-1-Propyne) Membrane Regeneration Process, Andrei G. Fadeev, Michael M. Meagher
Poly (1-Trimethysilyl-1-Propyne) Membrane Regeneration Process, Andrei G. Fadeev, Michael M. Meagher
Department of Chemical and Biomolecular Engineering: Faculty Publications
A novel process for the regeneration of PTMSP membranes is disclosed. The regeneration process includes washing a fouled PTMSP membrane with a solution containing at least about 50% butanol in water for a time sufficient to increase the flux and/or selectivity of the membrane. This regeneration process with a butanol containing solution significantly improves both the flux and selectivity of the PTMSP membrane and can regenerate the flux of the PTMSP membrane to the level of a previously unused membrane.
Nano-Devices Using Block-Copolymers, Ravi F. Saraf
Nano-Devices Using Block-Copolymers, Ravi F. Saraf
Department of Chemical and Biomolecular Engineering: Patents
A structure including a substrate. A first electrode and a second electrode are arranged spaced apart from each other on the substrate. A polymer string is positioned on the substrate between the two electrodes, the polymer line has a width of less than about 50 nm.
Thermodynamics And Bioenergetics, Yaşar Demirel, Stanley I. Sandler
Thermodynamics And Bioenergetics, Yaşar Demirel, Stanley I. Sandler
Papers in Thermal Mechanics
Bioenergetics is concerned with the energy conservation and conversion processes in a living cell, particularly in the inner membrane of the mitochondrion. This review summarizes the role of thermodynamics in understanding the coupling between the chemical reactions and the transport of substances in bioenergetics. Thermodynamics has the advantages of identifying possible pathways, providing a measure of the efficiency of energy conversion, and of the coupling between various processes without requiring a detailed knowledge of the underlying mechanisms. In the last five decades, various new approaches in thermodynamics, non-equilibrium thermodynamics and network thermodynamics have been developed to understand the transport and …
Thermodynamics And Bioenergetics, Yaşar Demirel, Stanley I. Sandler
Thermodynamics And Bioenergetics, Yaşar Demirel, Stanley I. Sandler
Papers in Thermal Mechanics
Bioenergetics is concerned with the energy conservation and conversion processes in a living cell, particularly in the inner membrane of the mitochondrion. This review summarizes the role of thermodynamics in understanding the coupling between the chemical reactions and the transport of substances in bioenergetics. Thermodynamics has the advantages of identifying possible pathways, providing a measure of the efficiency of energy conversion, and of the coupling between various processes without requiring a detailed knowledge of the underlying mechanisms. In the last five decades, various new approaches in thermodynamics, non-equilibrium thermodynamics and network thermodynamics have been developed to understand the transport and …
Expression Of Active Human Factor Ix In Mammary Tissue And Of Milk Non Human Transgenic Mammals, William H. Velander
Expression Of Active Human Factor Ix In Mammary Tissue And Of Milk Non Human Transgenic Mammals, William H. Velander
Department of Chemical and Biomolecular Engineering: Patents
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes Factor IX, such that the foreign DNA is stably incorporated in the DNA of germ line cells of the mature animal. Particularly efficient expression was accomplished using a chimeric construct comprising a mammary gland specific promoter, Factor IX cDNA that lacked the complete or any portion of the 5'-untranslated and 3'-untranslated region, which is …
Expression Of Active Human Factor Ix In Mammary Tissue And Of Milk Non Human Transgenic Mammals , William H. Velander, William N. Drohan
Expression Of Active Human Factor Ix In Mammary Tissue And Of Milk Non Human Transgenic Mammals , William H. Velander, William N. Drohan
Papers in Biotechnology
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes Factor IX, such that the foreign DNA is stably incorporated in the DNA of germ line cells of the mature animal. Particularly efficient expression was accomplished using a chimeric construct comprising a mammary gland specific promoter, Factor IX cDNA that lacked the complete or any portion of the 5'-untranslated and 3'-untranslated region, which is …
Solitary Waves And Supersonic Reaction Front In Metastable Solids, Hendrik J. Viljoen, Lee L. Lauderback, Didier Sornette
Solitary Waves And Supersonic Reaction Front In Metastable Solids, Hendrik J. Viljoen, Lee L. Lauderback, Didier Sornette
Papers in Solid Phase Dynamics
Motivated by an increasing number of remarkable experimental observations on the role of pressure and shear stress in solid reactions, explosions, and detonations, we present a simple one-dimensional model that embodies nonlinear elasticity and dispersion as well as chemical or phase transformation. This generalization of the Toda lattice provides an effective model for the description of the organization during an abrupt transformation in a solid. One of the challenges is to capture both the equilibrium degrees of freedom as well as to quantify the possible role of out-of-equilibrium perturbations. In the Toda lattice, we verify that the particle velocities converge …