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Articles 1 - 12 of 12
Full-Text Articles in Engineering
Protein Sequence-Structure-Function Relationship: Testing Ke-50 Modification On Recombinant Green Fluorescent Protein (Acgfp), Anna E. Burkey
Protein Sequence-Structure-Function Relationship: Testing Ke-50 Modification On Recombinant Green Fluorescent Protein (Acgfp), Anna E. Burkey
Williams Honors College, Honors Research Projects
Protein modification shows promise for improving the effectiveness of protein therapy, including the use of Interferon-beta-1b for the treatment of multiple sclerosis. The addition of a chain of 50 lysine and glutamic acid residues (also called a KE50 modification) was tested on green fluorescent protein (AcGFP) to determine its effect on the bioactivity of the protein. Standard transformation protocol was used to grow the normal and modified proteins in E.Coli, and the bioactivity of the protein was measured using quantum yield and extinction coefficients to determine the reduction in brightness from the native form to the modified form. The …
Calcium Alginate Microbead Production Via An Air Assisted Shearing Process, Ryan Loftus
Calcium Alginate Microbead Production Via An Air Assisted Shearing Process, Ryan Loftus
Williams Honors College, Honors Research Projects
The purpose of this project was to model the size of calcium alginate microbeads produced by extruding a solution of 1.5 wt.% alginate from a syringe and needle with air shear generated from a pneumatic line flowing in an annular tube around the extrusion needle. The air shear would create microdroplets that would fall into a solution of 2 wt.% calcium chloride in water, crosslinking the droplets into beads. These microbeads can be used in drug dispersion applications or in encapsulation of cells throughout the body due to their biocompatibility. The goal was to create uniform beads that ranged from …
Investigation Of Degradation Of Amine Sorbent, Elijah Arendt
Investigation Of Degradation Of Amine Sorbent, Elijah Arendt
Williams Honors College, Honors Research Projects
The purpose of this study is to investigate the performance of amine-grafted sorbents, specifically when they are degraded at 120°C. This study varied the amine source and the amount of it in the sorbent. The additive type and the amount of it was also manipulated. The performance of sorbents is characterized by CO2 capture capacity, which is the amount (in mmol) of CO2 captured per gram of sorbent at 40°C. The best performing sorbents are ones that maintain their CO2 capture capacity after degradation. When the amount of additive was manipulated, the sorbents containing 2% b.w. and …
The Effect Of Drying On The Release Of Small Hydrophilic Molecular Drugs From Polyelectrolyte Complex Beads, Dounsavanh Letdara
The Effect Of Drying On The Release Of Small Hydrophilic Molecular Drugs From Polyelectrolyte Complex Beads, Dounsavanh Letdara
Williams Honors College, Honors Research Projects
The effects of bead composition and dryness on the release rate of small molecules, like a drug or dye, from polyelectrolyte complex (PEC) beads were studied. Release studies were performed on dried and not dried beads prepared using different PEC to drug ratios. The beads were dried for two hours, which allowed them to reach a constant weight. The beads were loaded with a dye, so their release could be detected through the visible light regime. A plate reader was used to determine the absorbance of a sample, and then the amount of dye released was determined. The data presented …
Passivation And Potential Fluctuation Of Az31b Alloy In Alkaline Environments, Ana C. Bacco
Passivation And Potential Fluctuation Of Az31b Alloy In Alkaline Environments, Ana C. Bacco
Williams Honors College, Honors Research Projects
Magnesium (Mg) alloys are used in many industries because of their distinctive properties, but their high chemical reactivity and poor oxide film protection make them inferior. This project focused on investigating the effects of secondary phases and intermetallic particles (IMPs) on the corrosion behavior of AZ31B Mg alloy. The test solution was chloride free NaOH with varying pH levels between 10-14, as well as testing under deaerated conditions. The open circuit potential (OCP) measurements using AZ31B in static NaOH solutions showed potential fluctuation between approximately -1.6 VSCE (active state) and -0.4 VSCE (passive state) during the 24-h immersion. …
Prediction Of Vapor/Liquid Equilibrium Behavior From Quantum Mechanical Data, Marshall J. Gnap
Prediction Of Vapor/Liquid Equilibrium Behavior From Quantum Mechanical Data, Marshall J. Gnap
Williams Honors College, Honors Research Projects
MOSCED (Modified Separation of Cohesive Energy Density) is a particularly attractive model for activity coefficients because it offers intuitive insights into how to tune solvent-solute interactions to achieve optimized formulations. Unfortunately, only 133 compounds have been characterized with the MOSCED method. Furthermore, there is no convenient method for extending MOSCED predictions to new compounds. The hypothesis of the present research is that the surface charge density of a molecule, once normalized over the molecule surface area, provided graphically by a σ-profile from density functional theory (DFT) computations, can be used to estimate the parameters used in the MOSCED model. DFT …
Construction Of Polyurethane Fabric Nanocomposites For Use In Resistance Temperature Detectors-Effect Of Polyurethane Concentration, Multi-Walled Carbon Nanotubes, And Oxidant, Jordan M. Shaffer
Williams Honors College, Honors Research Projects
Current resistance temperature detectors (RTDs) are rigid and create pressure points when used in contact with the human body. The current RTDs can also not be used in confined areas like the inside of a prosthetic. The research done for this paper explores the possibility of creating a soft fabric like RTD that can accurately measure temperature. This RTD could be used in medical devices, be placed in prosthetic legs, and be worn for a long period of time creating no discomfort for the user. Polyurethane scaffolds were created through an electrospinning process and multiwalled carbon nanotubes were adhered to …
Separation Of Water From Ulsd Using Superhydrophobic Ps Nanofiber Mats, Alisa G. Webel
Separation Of Water From Ulsd Using Superhydrophobic Ps Nanofiber Mats, Alisa G. Webel
Williams Honors College, Honors Research Projects
Superhydrophobic polystyrene nanofiber membranes have potential to separate micron scale water droplets from organic due to their hydrophobicity and small pore openings. Polystyrene nanofibers were electrospun into flat sheets and cylindrical filter membranes. The fibers were crosslinked to increase strength and reduce solubility in diesel fuel. The filters were tested and the filtration efficiency was compared to their non-crosslinked counterparts. The optimal electrospinning conditions to create superhydrophobic nanofibers were found to be 20 wt. % PS fibers at 1 mL/hr. under a current of 20kV and at a distance of 20 cm away from the ground. It was found that …
Microbiologically Influenced Corrosion: Rhamnolipid Effects, Andrea M. Wildroudt
Microbiologically Influenced Corrosion: Rhamnolipid Effects, Andrea M. Wildroudt
Williams Honors College, Honors Research Projects
The purpose of this experiment was to identify if a rhamnolipid could inhibit the growth of a biofilm on carbon steel coupons and result in less corrosion activity. This type of research impacts various industries (with one of the largest being the oil and gas industry). Multiple systems with varying concentrations of the rhamnolipid were created to determine, if any, the optimum concentration to inhibit biofilm growth. The systems were created and exposed to optimum physio-chemical environments to promote SRB induced corrosion. Coupons were immersed for 28 days. Seven systems were created with varying rhamnolipid concentrations; to ensure accurate results, …
Stress Corrosion Cracking Evaluation Of Carbon Steel In Biodiesel And The Effect Of Ultrasonic Nanocrystal Surface Modification (Unsm) On 304 Stainless Steel, Josh Geyer
Williams Honors College, Honors Research Projects
The project that was performed was stress corrosion cracking (SSC) of carbon steel in biodiesel, petroleum diesel and a mixture. The project also included the effect of Ultrasonic Nanocrystal Surface Modification (UNSM) on 304 stainless steel. It included the assembly of a slow strain rate (SSR) machine and carrying out testing using the SSR machine. The assembly of the machine will require purchasing and building a stand to house the electrical equipment which includes the computer, actuator control panel and the actuator power supply. The assembly will also include designing and purchasing the connections to connect the actuator to the …
Thermal Responsive Release Of A Model Drug, Rhoadmine B, From Alginate Bead System, Heather F. Fairbairn Miss
Thermal Responsive Release Of A Model Drug, Rhoadmine B, From Alginate Bead System, Heather F. Fairbairn Miss
Williams Honors College, Honors Research Projects
Smart drug delivery systems have garnered increased interest in the biomedical community during recent years. Investigation into thermal, pH, and light responsive delivery systems allows for targeted drug release systems to be developed. For this project, thermal responsive release behavior was investigated for the purpose of tuning release systems to achieve 60% release in a specified time by varying the content of thermal responsive polymer. To investigate this, the release profile of a model small hydrophilic drug (rhodamine B) from polymeric alginate beads that have been modified by the addition of thermal responsive poly(N-isopropylacrylamide) (PNIPAAm). It was determined that when …
Selective, Catalytic Decomposition Of Hydrazine, Benjamin A. Kitson, Shirin N. Oliaee
Selective, Catalytic Decomposition Of Hydrazine, Benjamin A. Kitson, Shirin N. Oliaee
Williams Honors College, Honors Research Projects
The selective, catalytic decomposition of hydrazine has been investigated using a 1 wt% Pt-Ni(OH)2 catalyst system quantitatively studied by changing the following parameters; reaction solution alkalinity, temperature, hydrazine concentration, catalyst selectivity, catalyst stability, and catalyst durability. Using sodium hydroxide (NaOH), the best alkalinity was found to be 1 M NaOH. The optimal temperature was found to be 50 °C for complete hydrazine conversion. A hydrazine concentration of 0.1 M produced the most effective reaction. The catalyst was found to be completely selective in hydrogen and nitrogen production with no ammonia formation. The catalyst activity decreased by 15% after 8 …