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Articles 1 - 19 of 19
Full-Text Articles in Engineering
Evolutionary View Planning For Optimized Uav Terrain Modeling In A Simulated Environment, Ronald A. Martin, Ivan Rojas, Kevin W. Franke, John Hedengren
Evolutionary View Planning For Optimized Uav Terrain Modeling In A Simulated Environment, Ronald A. Martin, Ivan Rojas, Kevin W. Franke, John Hedengren
Faculty Publications
This work demonstrates the use of genetic algorithms in optimized view planning for 3D reconstruction applications using small unmanned aerial vehicles (UAVs). The quality of UAV site models is currently highly dependent on manual pilot operations or grid-based automation solutions. When applied to 3D structures, these approaches can result in gaps in the total coverage or inconsistency in final model resolution. Genetic algorithms can effectively explore the search space to locate image positions that produce high quality models in terms of coverage and accuracy. A fitness function is defined, and optimization parameters are selected through semi-exhaustive search. A novel simulation …
Effects Of Tethering Placement And Linker Variations On Antibody Stability On Surfaces, Rebecca Ellen Grawe
Effects Of Tethering Placement And Linker Variations On Antibody Stability On Surfaces, Rebecca Ellen Grawe
Theses and Dissertations
An antibody microarray consists of antibody bound to a surface. Antibody microarrays have great potential in many fields, particularly as a tool to detect antigens. Unfortunately, antibodies suffer from poor performance. A greater understanding of how antibodies interact with surfaces would improve microarray design and performance, but experimental methods fall short of being able to observe these interactions. Therefore molecular simulation has emerged as the primary method to study protein/surface interactions.The simulations here were coarse grain simulations performed using the model of Karanicolas and Brooks. Additionally, an advanced surface model was used that allows for different surface chemistries. PyMBAR analysis …
How A Systematic Approach To Uncertainty Quantification Renders Molecular Simulation A Quantitative Tool In Predicting The Critical Constants For Large N-Alkanes, Richard Alma Messerly
How A Systematic Approach To Uncertainty Quantification Renders Molecular Simulation A Quantitative Tool In Predicting The Critical Constants For Large N-Alkanes, Richard Alma Messerly
Theses and Dissertations
Accurate thermophysical property data are crucial for designing efficient chemical processes. For this reason, the Design Institute for Physical Properties (DIPPR 801) provides evaluated experimental data and prediction of various thermophysical properties. The critical temperature (Tc), critical density (ρc), critical pressure (Pc), critical compressibility factor (Zc), and normal boiling point (Tb) are important constants to check for thermodynamic consistency and to estimate other properties. The n-alkane family is of primary interest because it is generally assumed that other families of compounds behave similarly to …
Nanoemulsions Within Liposomes For Cytosolic Drug Delivery To Multidrug-Resistant Cancer Cells, Jacob Brian Williams
Nanoemulsions Within Liposomes For Cytosolic Drug Delivery To Multidrug-Resistant Cancer Cells, Jacob Brian Williams
Theses and Dissertations
Cancer cells that survive chemotherapy treatment often develop resistance to the administered chemotherapeutics, as well as to many other types of drugs, because the cancer cells increase their production of efflux pumps in the cell. This undesired phenomenon of resistance to cancer drugs is known as multidrug resistance. This work uses a novel drug carrier, called an eLiposome, to achieve cytosolic drug delivery to kill multidrug-resistant cancer cells. An eLiposome consists of a perfluoropentane (PFC5) emulsion droplet inside of a liposome. Folate attached to the eLiposome facilitates uptake into the cell. The PFC5 droplet is metastable at body temperature, but …
Development And Optimization Of Voltammetry For Real Time Analysis Of Multi-Component Electrorefiner Salt, Chao Zhang, Devin Rappleye, Michael F. Simpson
Development And Optimization Of Voltammetry For Real Time Analysis Of Multi-Component Electrorefiner Salt, Chao Zhang, Devin Rappleye, Michael F. Simpson
Faculty Publications
Normal pulse voltammetry was performed on LiCl-KCl-UCl3- MgCl2 molten salt mixtures while varying parameters such as pulse time, relaxation potential, and interval time. Concentrations of UCl3 up to 7 wt% were tested with a fixed 1.5 wt% MgCl2 concentration. The correlation between diffusion limited partial current density to UCl3 concentration exhibited an excellent fit to a 2nd order polynomial. A similar fit was obtained for the correlation between MgCl2 concentration and the diffusion limited partial current density at a fixed UCl3 concentration of 1.0 wt%.
Application Of Voltammetry For Electroanalytical Measurement Of Concentrations In Lacl3-Mgcl2 Mixtures In Eutectic Licl-Kcl, Zhonghang Wang, Devin Rappleye, C S. Yang, Michael Simpson
Application Of Voltammetry For Electroanalytical Measurement Of Concentrations In Lacl3-Mgcl2 Mixtures In Eutectic Licl-Kcl, Zhonghang Wang, Devin Rappleye, C S. Yang, Michael Simpson
Faculty Publications
For electroanalytical measurement of molten chloride salts, various voltammetry methods have been used on mixtures of MgCl2 and LaCl3 in eutectic LiCl-KCl. These salt mixtures are of primary interest to spent nuclear fuel electrorefining systems. MgCl2 is used as a surrogate for PuCl3, while LaCl3 represents rare earth fission product salts. Cyclic voltammetry scans with these salt mixtures exhibited extra peaks, presumably due to underpotential deposition of La(III) ions onto Mg. Quantitatively, the current contribution from each peak was best determined using normal pulse voltammetry and fit to the Cottrell equation. This yielded linear …
Comparison Of Sfm Computer Vision Point Clouds Of A Landslide Derived From Multiple Small Uav Platforms And Sensors To A Tls Based Model, Samantha Ruggles, Joseph Clark, Kevin W. Franke, Derek Wolfe, Brandon Reimschiissel, Ronald Abraham Martin, Trent Okeson, John Hedengren
Comparison Of Sfm Computer Vision Point Clouds Of A Landslide Derived From Multiple Small Uav Platforms And Sensors To A Tls Based Model, Samantha Ruggles, Joseph Clark, Kevin W. Franke, Derek Wolfe, Brandon Reimschiissel, Ronald Abraham Martin, Trent Okeson, John Hedengren
Faculty Publications
Structure from motion (SfM) computer vision is a remote sensing method that is gaining popularity due to its simplicity and ability to accurately characterize site geometry in three dimensions (3D). While many researchers have demonstrated the potential for SfM to be used with unmanned aerial vehicles (UAVs) to model in three dimensions various geologic features such as landslides, little is understood how the selection of the UAV platform can affect the resolution and accuracy of the model. This study evaluates the resolution and accuracy of 3D point cloud models of a large landslide that occurred in 2013 near Page, Arizona …
Thermal And Convective Loading Methods For Releasing Hydrophobic Therapeutics From Contact Lenses, Ryan Ruben Horne
Thermal And Convective Loading Methods For Releasing Hydrophobic Therapeutics From Contact Lenses, Ryan Ruben Horne
Theses and Dissertations
This thesis investigates the feasibility of loading silicone hydrogel (SiHy) contact lenses with two different hydrophobic therapeutics, latanoprost and DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine), for treatment of glaucoma and hyperemia respectively. The two methods of loading were 1) thermal loading in an aqueous medium and 2) convective loading in a solution of n-propanol. Dailies Total1® lenses prepared in this manner were tested for their loading and their release into artificial tears. Continuous release over 1-4 days at therapeutic levels is achievable from thermal loading of DMPC, convective loading of DMPC, and convective loading of latanoprost. The DMPC loading processes can be naturally integrated …
Dynamic Liquefied Natural Gas (Lng) Processing With Energy Storage Applications, Farhad Fazlollahi
Dynamic Liquefied Natural Gas (Lng) Processing With Energy Storage Applications, Farhad Fazlollahi
Theses and Dissertations
The cryogenic carbon capture™ (CCC) process provides energy- and cost-efficient carbon capture and can be configured to provide an energy storage system using an open-loop natural gas (NG) refrigeration system, which is called energy storing cryogenic carbon capture (CCC-ES™). This investigation focuses on the transient operation and especially on the dynamic response of this energy storage system and explores its efficiency, effectiveness, design, and operation. This investigation included four tasks.The first task explores the steady-state design of four different natural gas liquefaction processes simulated by Aspen HYSYS. These processes differ from traditional LNG process in that the CCC process vaporizes …
Nerve Regeneration Using Lysophosphatidylcholine And Nerve Growth Factor, Ryan Lavar Wood
Nerve Regeneration Using Lysophosphatidylcholine And Nerve Growth Factor, Ryan Lavar Wood
Theses and Dissertations
Peripheral nerve damage affects hundreds of thousands of people every year. This study tested the effectiveness of using lysophosphatidylcholine (LPC) in combination with nerve growth factor (NGF) to increase the healing rate of damaged left sciatic nerves in female rats. The rats were randomly divided into eight groups: Sham, Right Sciatic, Crush, LPC, LPC-NGF, Crush- LPC, Crush-NGF, and Crush-LPC-NGF. The healing of the nerves was measured by monitoring gait, electrophysiological parameters (compound muscle action potential amplitudes and nerve conductance velocities) and morphological parameters (total fascicular area, total myelinated fiber counts, fiber densities, fiber diameters, and g-ratio). Gait and electrophysiological parameters …
Developing Modeling, Optimization, And Advanced Process Control Frameworks For Improving The Performance Of Transient Energy-Intensive Applications, Seyed Mostafa Safdarnejad
Developing Modeling, Optimization, And Advanced Process Control Frameworks For Improving The Performance Of Transient Energy-Intensive Applications, Seyed Mostafa Safdarnejad
Theses and Dissertations
The increasing trend of world-wide energy consumption emphasizes the importance of ongoing optimization of new and existing technologies. In this dissertation, two energy–intensive systems are simulated and optimized. Advanced estimation, optimization, and control techniques such as a moving horizon estimator and a model predictive controller are developed to enhance the profitability, product quality, and reliability of the systems. An enabling development is presented for the solution of complex dynamic optimization problems. The strategy involves an initialization approach to large–scale system models that both enhance the computational performance as well as the ability of the solver to converge to an optimal …
Mitigating Transients And Azeotropes During Natural Gas Processing, Edris Ebrahimzadeh
Mitigating Transients And Azeotropes During Natural Gas Processing, Edris Ebrahimzadeh
Theses and Dissertations
Cryogenic carbon capture process can be used to efficiently eliminate CO2 emissions from fossil-fueled power plants. The energy-storing embodiment of cryogenic carbon capture (ES-CCC) integrates energy storage with cryogenic carbon capture and uses natural gas as a refrigerant. ES-CCC captures CO2 from slowly varying or steady-state sources even as it absorbs and replaces large amounts of energy on the grid for energy storage. These large transients occur in the LNG generation as the process moves through energy storing to energy recovery operations. Additionally, raw natural gas often includes CO2 that forms an azeotrope with ethane. Breaking this azeotrope and separating …
A Continuous Formulation For Logical Decisions In Differential Algebraic Systems Using Mathematical Programs Of Complementarity Constraints, Kody Powell, Ammon N. Eaton, John Hedengren, Thomas F. Edgar
A Continuous Formulation For Logical Decisions In Differential Algebraic Systems Using Mathematical Programs Of Complementarity Constraints, Kody Powell, Ammon N. Eaton, John Hedengren, Thomas F. Edgar
Faculty Publications
This work presents a methodology to represent logical decisions in differential algebraic equation simulation and constrained optimization problems using a set of continuous algebraic equations. The formulations may be used when state variables trigger a change in process dynamics, and introduces a pseudo-binary decision variable, which is continuous, but should only have valid solutions at values of either zero or one within a finite time horizon. This formulation enables dynamic optimization problems with logical disjunctions to be solved by simultaneous solution methods without using methods such as mixed integer programming. Several case studies are given to illustrate the value of …
Aminoacyl-Trna Synthetase Production For Unnatural Amino Acid Incorporation And Preservation Of Linear Expression Templates In Cell-Free Protein Synthesis Reactions, Andrew Broadbent
Theses and Dissertations
Proteins—polymers of amino acids—are a major class of biomolecules whose myriad functions facilitate many crucial biological processes. Accordingly, human control over these biological processes depends upon the ability to study, produce, and modify proteins. One innovative tool for accomplishing these aims is cell-free protein synthesis (CFPS). This technique, rather than using living cells to make protein, simply extracts the cells' natural protein-making machinery and then uses it to produce protein in vitro. Because living cells are no longer involved, scientists can freely adapt the protein production environment in ways not otherwise possible. However, improved versatility and yield of CFPS protein …
Extracellular Matrix From Whole Porcine Heart Decellularization For Cardiac Tissue Engineering, Nima Momtahan
Extracellular Matrix From Whole Porcine Heart Decellularization For Cardiac Tissue Engineering, Nima Momtahan
Theses and Dissertations
Heart failure is one of the leading causes of death in the United States. Every year in the United States, more than 800,000 people are diagnosed with heart failure and more than 375,000 people die from heart disease. Current therapies such as heart transplants and bioartificial hearts are helpful, but not optimal. Decellularization of porcine whole hearts followed by recellularization with patient-specific human cells may provide the ultimate solution for patients with heart failure. Great progress has been made in the development of efficient processes for decellularization, and the design of automated bioreactors. In this study, the decellularization of porcine …
The Influence Of Season, Heating Mode And Slope Angle On Wildland Fire Behavior, Jonathan R. Gallacher
The Influence Of Season, Heating Mode And Slope Angle On Wildland Fire Behavior, Jonathan R. Gallacher
Theses and Dissertations
Wildland fire behavior research in the last 100 years has largely focused on understanding the physical phenomena behind fire spread and on developing models that can predict fire behavior. Research advances in the areas of live-fuel combustion and combustion modeling have highlighted several weaknesses in the current approach to fire research. Some of those areas include poor characterization of solid fuels in combustion modeling, a lack of understanding of the dominant heat transfer mechanisms in fire spread, a lack of understanding regarding the theory of live-fuel combustion, and a lack of understanding regarding the behavior of flames near slopes. In …
Global Sensitivity Analysis For A Comprehensive Char Conversion Model In Oxy-Fuel Conditions, Troy Michael Holland, Thomas H. Fletcher
Global Sensitivity Analysis For A Comprehensive Char Conversion Model In Oxy-Fuel Conditions, Troy Michael Holland, Thomas H. Fletcher
Faculty Publications
Oxy-fired coal combustion is a promising potential carbon capture technology. Predictive CFD simulations are valuable tools in evaluating and deploying oxy-fuel and other carbon capture technologies either as retrofit technologies or for new construction. However, accurate predictive simulations require physically realistic submodels with low computational requirements. In particular, comprehensive char oxidation and gasification models have been developed that describe multiple reaction and diffusion processes. This work focuses on the sensitivity of a recent comprehensive char conversion code named CCK, which treats surface oxidation and gasification reactions as well as the processes such as film diffusion, pore diffusion, ash encapsulation, and …
Independent Effects Of Surface And Gas Temperature On Coal Fly Ash Deposition In Gas Turbines At Temperatures Up To 1400 C, Robert Laycock, Thomas H. Fletcher
Independent Effects Of Surface And Gas Temperature On Coal Fly Ash Deposition In Gas Turbines At Temperatures Up To 1400 C, Robert Laycock, Thomas H. Fletcher
Faculty Publications
Deposition of coal fly ash in gas turbines has been studied to support the concept of integrated gasification combined cycle (IGCC). Although particle filters are used in IGCC, small amounts of ash particles less than 5 microns in diameter enter the gas turbine. Previous deposition experiments in the literature have been conducted at temperatures up to about 1288 C. However, few tests have been conducted that reveal the independent effects of gas and surface temperature, and most have been conducted at gas temperatures lower than 1400 C. The independent effects of gas and surface temperature on particle deposition in a …
A Comparison Of Simple Global Kinetic Models For Coal Devolatilization With The Cpd Model, Andrew Richards, Thomas H. Fletcher
A Comparison Of Simple Global Kinetic Models For Coal Devolatilization With The Cpd Model, Andrew Richards, Thomas H. Fletcher
Faculty Publications
Simulations of coal combustors and gasifiers generally cannot incorporate the complexities of advanced pyrolysis models, and hence there is interest in evaluating simpler models over ranges of temperature and heating rate that are applicable to the furnace of interest. In this paper, six different simple model forms are compared to predictions made by the Chemical Percolation Devolatilization (CPD) model. The model forms included three modified one-step models, a simple two-step model, and two new modified two-step models. These simple model forms were compared over a wide range of heating rates (5000 to 106 K/s) at final temperatures up to …