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Articles 1 - 8 of 8
Full-Text Articles in Engineering
A Nonlinear Systems Framework For Cyberattack Prevention For Chemical Process Control Systems, Helen Durand
A Nonlinear Systems Framework For Cyberattack Prevention For Chemical Process Control Systems, Helen Durand
Chemical Engineering and Materials Science Faculty Research Publications
Recent cyberattacks against industrial control systems highlight the criticality of preventing future attacks from disrupting plants economically or, more critically, from impacting plant safety. This work develops a nonlinear systems framework for understanding cyberattack-resilience of process and control designs and indicates through an analysis of three control designs how control laws can be inspected for this property. A chemical process example illustrates that control approaches intended for cyberattack prevention which seem intuitive are not cyberattack-resilient unless they meet the requirements of a nonlinear systems description of this property.
Economic Model Predictive Control Design Via Nonlinear Model Identification, Laura Giuliani, Helen Durand
Economic Model Predictive Control Design Via Nonlinear Model Identification, Laura Giuliani, Helen Durand
Chemical Engineering and Materials Science Faculty Research Publications
Increasing pushes toward next-generation/smart manufacturing motivate the development of economic model predictive control (EMPC) designs which can be practically deployed. For EMPC, the constraints, objective function, and accuracy of the state predictions would benefit from process models that describe the process physics. However, obtaining first- principles models of chemical process systems can be time-consuming or challenging such that it is preferable to develop physics-based process models automatically from process operating data. In this work, we take initial steps in this direction by suggesting that because experiments that are used to characterize first-principles models often target specific types of data, an …
State Measurement Spoofing Prevention Through Model Predictive Control Design, Helen Durand
State Measurement Spoofing Prevention Through Model Predictive Control Design, Helen Durand
Chemical Engineering and Materials Science Faculty Research Publications
Security of chemical process control systems against cyberattacks is critical due to the potential for injuries and loss of life when chemical process systems fail. A potential means by which process control systems may be attacked is through the manipulation of the measurements received by the controller. One approach for addressing this is to design controllers that make manipulating the measurements received by the controller in any meaningful fashion very difficult, making the controllers a less attractive target for a cyberattack of this type. In this work, we develop a model predictive control (MPC) implementation strategy that incorporates Lyapunov-based stability …
Data-Based Nonlinear Model Identification In Economic Model Predictive Control, Laura Giuliani, Helen Durand
Data-Based Nonlinear Model Identification In Economic Model Predictive Control, Laura Giuliani, Helen Durand
Chemical Engineering and Materials Science Faculty Research Publications
Many chemical/petrochemical processes in industry are not completely modeled from a first-principles perspective because of the complexity of the underlying physico-chemical phenomena and the cost of obtaining more accurate, physically relevant models. System identification methods have been utilized successfully for developing empirical, though not necessarily physical, models for advanced model-based control designs such as model predictive control (MPC) for decades. However, a fairly recent development in MPC is economic model predictive control (EMPC), which is an MPC formulated with an economics-based objective function that may operate a process in a dynamic (i.e., off steady-state) fashion, in which case the details …
Cfd/Fea Of A Steam Methane Reforming Tube, Matthew Wegener
Cfd/Fea Of A Steam Methane Reforming Tube, Matthew Wegener
Research Opportunities for Engineering Undergraduates (ROEU) Program 2017-18
Steam methane reforming is the primary method by which hydrogen is produced; increased efficiency in hydrogen production could enable hydrogen’s usage as an alternative fuel. The objectives of this project are to construct a robust CFD/FEA model of a steam methane reforming tube, and to perform CFD/FEA analysis in both steady and transient operational states, comparing thermal stresses/strains in the tube wall in the two states and relating tube stresses/strains to properties of the process controller.
Zwitterionic Polymer For Drug Delivery Applications, Yang Lu
Zwitterionic Polymer For Drug Delivery Applications, Yang Lu
Wayne State University Dissertations
This dissertation focuses on the applications of zwitterionic polymer materials in drug delivery. In one project, zwitterionic polymer was used to construct micelle surfactants. The zwitterionic micelles were found to have an ultralow critical micelle concentration (CMC). Potential mechanism for zwitterionic micelles achieving the ultralow CMC property has been studied. Based on the ultralow CMC feature, zwitterionic micelles were used to prepare a formulation of commercial antitumor drug docetaxel, and the resulting formulation showed excellent antitumor performance. In another project, zwitterionic polymer was used to modify protein drug insulin via conjugation reaction. Compared with current protein modification methods, such as …
Maximum Recovery Of Mechanical Energy Through Work Integration: A Work Exchange Network Synthesis Approach, Aida Amini Rankouhi
Maximum Recovery Of Mechanical Energy Through Work Integration: A Work Exchange Network Synthesis Approach, Aida Amini Rankouhi
Wayne State University Dissertations
Sustainable development has become a key concern in industries, largely due to natural resource depletion, global competition, and environmental pressure. Despite the efforts for sustainability improvement, still over a half of energy consumption is wasted in manufacturing sectors, where the chemical industry is responsible for an energy efficiency lower than it should be. Many attempts have been made to recover the thermal energy using heat integration techniques. Although process work is more expensive than process heat, no efficient solution has been studied to recover mechanical energy yet. In chemical plants, many process streams need to be pressurized or depressurized in …
Drug Delivery Strategies For The Treatment Of Advanced Lung Cancer And Various Lung Metastases, Elizabeth Bielski
Drug Delivery Strategies For The Treatment Of Advanced Lung Cancer And Various Lung Metastases, Elizabeth Bielski
Wayne State University Dissertations
Lung cancer remains the leading cause of cancer-related deaths in the United States. Secondary lung tumors metastasized from other cancer sites also remains highly prevalent, in which most metastatic tumors cannot be cured with existing therapies. Chemoresistance (multi drug resistance – MDR) that develops intrinsically or acquired is one of the key factors leading to fatality in these patients. MDR develops form a variety of resistance mechanisms that can occur consecutively or concurrently, therefore, making most current treatments unsuccessful. Current therapies have known to slow tumor growth, but rarely provide a cure. Immunotherapy has seen some promise, including the use …