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Full-Text Articles in Engineering
Continuous Liquid-Liquid Extraction Of Lomustine Synthesis, Devna Grover
Continuous Liquid-Liquid Extraction Of Lomustine Synthesis, Devna Grover
The Journal of Purdue Undergraduate Research
No abstract provided.
Biomarkers For Vincristine-Induced Neuropathy, Danni Li, Jayachandran Devaraj, Doraiswami Ramkrishna
Biomarkers For Vincristine-Induced Neuropathy, Danni Li, Jayachandran Devaraj, Doraiswami Ramkrishna
The Summer Undergraduate Research Fellowship (SURF) Symposium
Vincristine is a vinca alkaloid, a commonly used chemotherapy drug for treating leukemia, lymphoma, multiple myeloma and some pediatric cancers. Its major dose-limiting side effect is peripheral neuropathy. The current dosing of “standard-dose-for-all” ignores the genetic and phenotypic variations among different patients, and causes severe neuropathy in some patients while ineffectively treats the others. In the present study, we aim to discover novel biomarkers involved in vincristine-induced neuropathy and identify patients with varied metabolic characteristics. Thus treatment can be tailored accordingly to improve outcomes of vincristine treatment. Pre-dose and post-dose serum samples were collected from two groups of patients (low …