Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Adenocarcinoma (1)
- Aplysia (1)
- Bmps (1)
- Buccal ganglia (1)
- CPG (1)
-
- CRC biomarkers (1)
- CRISPR-Cas9-mediated gene knock-in (1)
- Cell surface protein (1)
- Colonoscopy (1)
- Colorectal cancer (1)
- Computational (1)
- Drug resistance (1)
- Early detection (1)
- Endogenous expression of pro-metastatic BACH1 gene (1)
- Experimental evolution (1)
- Feeding behaviors (1)
- Gene expression noise (1)
- Ingestion (1)
- Mammalian synthetic gene circuits (1)
- Motor neurons (1)
- Neuroscience (1)
- Operant conditioning (1)
- Positive and negative feedback (1)
- Protein L microparticles (1)
- Protraction (1)
- Radula (1)
- Rejection (1)
- Retraction (1)
- Tumor heterogeneity (1)
Articles 1 - 3 of 3
Full-Text Articles in Engineering
Biophysical Model Of Retraction Motor Neurons And Their Modification By Operant Conditioning, Maria Rasheed
Biophysical Model Of Retraction Motor Neurons And Their Modification By Operant Conditioning, Maria Rasheed
Dissertations & Theses (Open Access)
Operant conditioning (OC) is a form of associative learning in which an animal modifies its behavior based on the consequences that follow that behavior. Despite its ubiquity, the underlying mechanisms of OC are poorly understood. Insights into the mechanisms of OC can be obtained by studying Aplysia feeding behavior as it can be modified by OC. This behavior is mediated by a central pattern generator (CPG) network in the buccal ganglia that contains a relatively small number of neurons. This CPG generates rhythmic motor patterns (BMPs) that move food into the gut by closing a tongue-like structure (i.e., radula) during …
Protein L Functionalized Microparticles For Early Detection Of Surface Markers In Heterogeneous Colorectal Lesions, Saleh Ramezani
Protein L Functionalized Microparticles For Early Detection Of Surface Markers In Heterogeneous Colorectal Lesions, Saleh Ramezani
Dissertations & Theses (Open Access)
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths among both men and women worldwide, a statistic that can be improved with early detection. Increased understanding of the tumor landscape has identified surface antigens that can be utilized to distinguish normal and cancerous tissue lining the colonic lumen. Use of antibodies conjugated to nano/micromaterials offers a means to detect these antigens, however, the heterogeneous nature of tumors makes it unlikely that antibodies against a single antigen will have sufficient sensitivity and specificity to detect all tumors. A versatile micromaterial able to be functionalized with more than one targeting …
The Role Of Gene Expression Noise In Mammalian Cell Survival, Kevin Farquhar
The Role Of Gene Expression Noise In Mammalian Cell Survival, Kevin Farquhar
Dissertations & Theses (Open Access)
Drug resistance and metastasis remain obstacles to effective cancer treatment. A major challenge contributing to this problem is cellular heterogeneity. Even in the same environment, cells with identical genomes can display cell-to-cell differences in gene expression, also known as gene expression noise. Gene expression noise can vary in magnitude in a population or in fluctuation time scales, which is influenced by gene regulatory networks.
Currently, it is unclear how gene expression noise from gene regulatory networks contributes to drug survival outcomes in mammalian cells. An isogenic cell line with a noise-modulating genetic system tuned to the same mean is required. …