Engineering Commons^™

Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb

Theses and Dissertations

Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …

Aerobic Exercise Improves Depressive Symptoms In The Unilateral 6-Ohda-Lesioned Rat Model Of Parkinson's Disease, Hannah Loughlin, Jacob Jackson, Chloe Looman, Alayna Starll, Jeremy Goldman, Zhiying Shan, Chunxiu Yu

Michigan Tech Publications, Part 2

Aerobic exercise has been shown to have established benefits on motor function in Parkinson's disease (PD). However, the impact of exercise on depressive symptoms in PD remains unclear. This study aimed to investigate the effects of regular exercise, specifically using a forced running wheel, on both motor performance and the prevalence of depression in a unilateral 6-OHDA-lesioned rat model of PD. The behavioral outcomes of exercise were assessed through the rotarod test (RT), forelimb adjusting step test (FAST), sucrose consumption test (SCT), and novelty sucrose splash test (NSST). Our data revealed evident depressive symptoms in the PD animals, characterized by …

Analyzing Heat Generated From Electro-Osmotic Flow Utilizing Computational Fluid Dynamics, Jordan Elizabeth Grothe

Honors Thesis

Without extensive vascularization, the transfer of fluid and nutrients through human tissue is limited to diffusion and weak interstitial flow. Electroosmosis, or the flow of fluid driven by an electrical field, has become a promising solution. Scientists have begun applying electricity to human tissue to promote stronger interstitial flow; however, optimization of this process has proven to be a challenge due to ohmic heating. Cells function within a small range of temperatures and exposure to voltages exceeding the threshold will cause cells to degrade and die prematurely. This research seeks to better understand and quantify the range of voltage where …

Analyzing Diverse Student Experiences: The Intersection Of Equity, Inclusivity, And Biomedical Engineering Education Through A Clinical Observations And Needs Finding Course, Jacquelynn Horsey

Biomedical Engineering Undergraduate Honors Theses

In the field of biomedical engineering, needs identification and solution development are an important element of the design process. In our undergraduate curriculum, a course was designed to allow clinical observation and provide an opportunity for students to learn about engineering design and engage with clinicians via completing rotations in medical facilities near our campus. While this type of course is not unique, evaluating its efficacy is not simple. Given the broad range of institutional resources available- such as proximity to a medical school, or residency programs- reporting the quality of such courses within the context of such available resources …

Uv-A Light: A Novel Method For Food Dehydration, Mckade S. Roberts

All Graduate Theses and Dissertations, Fall 2023 to Present

Dehydration is one of the most prevalent forms of food preservation, with approximately 85% of food is hot air drying due to the simplicity of the process. The high temperatures employed in this method may also induce a loss in nutritional quality, which involves destruction of micronutrients (vitamins), and loss of color.

The aim of this work is to develop a low energy, non-thermal method of food dehydration that results in a high-quality product through the application of Ultraviolet light, within the UV-A range. UV light can be separated into its 3 categories based on the wavelength of light from …

Mathematical Modeling For Dental Decay Prevention In Children And Adolescents, Mahdiyeh Soltaninejad

Dissertations

The high prevalence of dental caries among children and adolescents, especially those from lower socio-economic backgrounds, is a significant nationwide health concern. Early prevention, such as dental sealants and fluoride varnish (FV), is essential, but access to this care remains limited and disparate. In this research, a national dataset is utilized to assess sealants' reach and effectiveness in preventing tooth decay, particularly focusing on 2nd molars that emerge during early adolescence, a current gap in the knowledge base. FV is recommended to be delivered during medical well-child visits to children who are not seeing a dentist. Challenges and facilitators in …

Ambulatory Electrocardiographic Monitoring, Genesis V. Garay, Arath Sanchez

ATU Research Symposium

•Cardiovascular disease (CVD) is the world's leading cause of death, especially prevalent in low- and middle-income countries. Up to 80% of premature heart attacks and strokes are preventable. •Current ambulatory electrocardiographic (ECG) monitors, while effective in diagnosing heart rhythm issues, are often cost-prohibitive and have limitations like short monitoring periods, user-initiated recording, and offline data analysis. •This poster summarizes the foundation of the creation of a monitoring system that attempts to address these issues.

Tunable Dual-Phase Dual-Drug Delivery System Using A Plga Microparticle/Pva Hydrogel Composite, Timothy John Eck

Theses and Dissertations

Current drug-eluting coatings have demonstrated controlled long-term, sustained release but have only tried to mitigate short-term burst release as a negative side effect. For applications like wound healing, there is a need for a drug-eluting coating which is adjustable in both short- and long-term release, independent of each other. We present a tunable dual-phase dual-drug delivery coating composed of drug-loaded polymer microparticles and drug-loaded hydrogel which can control short term and long term release individually in this study. This coating was created using lidocaine and dexamethasone encapsulated in poly(D,L-lactide-co-glycolide) particles combined with lidocaine- and dexamethasone-loaded poly(vinyl alcohol) hydrogel. Hydrogel drug …

Bioactive And Electrically Conductive Nanocomposite Bone Biomaterials, Rebeca A. Arambula-Maldonado

Electronic Thesis and Dissertation Repository

Electrically conductive carbon-based materials are emerging as potential biomaterials for bone tissue engineering. Their incorporation into organic-inorganic nanocomposites mimics the structural composition and electrically conductive nature of bone.

The aim of this research was to design bone biomaterials from gelatin-based polymers, tertiary bioactive glasses (BG) via a sol-gel method, and multiwall carbon nanotubes (MWCNT). The incorporation of calcium into organic-inorganic nanocomposites plays an essential role in the development of bioactive bone biomaterials. Calcium chloride and calcium ethoxide were investigated as calcium sources in gelatin-BG-MWCNT nanocomposites. The resulting surface elemental distribution was homogeneous, but the swelling, degradation and porosity properties of …

Theory Of Development And Improvement Of The Mathematical Model Of The Methodology Of Public Control In The Management Of Occupational Safety And Industrial Risks, Aliakbar Khamidullaevich Rasulev, Sunnatilla Suleymanovich Suleymanov, Nodira Bakhadirzhanovna Gaibnazarova

Technical science and innovation

The article develops and analyzes a mathematical model based on a logical flowchart of the methodology of public control in the management of occupational safety and industrial risks and probability theory, according to the model, the results of compliance with the requirements of social cooperation on occupational safety lead to a sharp increase in the probability of reliability, management efficiency becomes higher. Analysis of the mathematical model of the developed logical flowchart based on probability theory has shown that when the parties cooperate to monitor the results of compliance with labor protection requirements, they lead to a sharp increase in …

Solving Water Resources Problems - Water Saving In The Republic Of Uzbekistan, Rustam Muxammatdjanovich Raximov

Technical science and innovation

In this article we will talk about the problems of water resources in the Republic of Uzbekistan. The problem of drinking water supply, solutions to provide drinking water to the population of Uzbekistan. The largest consumers of fresh water in Uzbekistan are farmers. Due to outdated infrastructure, 40% of water is wasted. Rising food prices and the risk of spreading disease are the first signs of water shortages that we may experience in the coming еars. Uzbekcosmos told how to solve the problem. Water is an invaluable resource used not only in the home, but also in the production and …

Selective Oxidation Of Iron In Chalcopyrite For Enhanced Copper Recovery, Khojiakbar Shuxrat O'G'Li Sultonov, Shokhrukh Toshpulatovich Khojiev, Gulnoza Berdiyor Qizi Beknazarova, Malika Sayfullayevna Saidova

Technical science and innovation

This study explores the thermodynamic feasibility of selectively oxidizing iron contained in chalcopyrite mineral while preventing the oxidation of copper sulphide, with the ultimate goal of enhancing the copper concentration in the sulphide concentrate. A redox reaction in the solid phases between chalcopyrite and copper (I) oxide was constructed and subjected to thermodynamic analysis. The research identifies a crucial temperature range of 498-598 K (225-325 °C) as the most favourable for the redox reaction. The equilibrium constants at the selected optimal temperatures, 1.152 for chalcopyrite and 1.137 for copper (I) oxide, indicate that the redox reaction adheres to the expected …

Modelling Of Heat Transfer In An Air Solar Collector, Shakhnoza Abduvaxitovna Sultanova, Jasur Esirgapovich Safarov, A.A. Mambetsheripova

Technical science and innovation

This study is the prediction, depending on time and different geographical and climatic situations, of different operating parameters: solar radiation, ambient and outlet coolant temperature, heat exchange coefficients and losses. All these determine, in the absence of measurements, the efficiency of the system modelled with existing models with respect to these parameters. These models are usually compared with experimental results. Before modelling, it is necessary to investigate the different heat transfer and exchange regimes that exist between the different elements of this system in order to eventually have a system of equations governing this exchange. The modelling principle is to …

Implementing A Solar Photovoltaic Station In Watering Systems Utilizing Complex Software, Akbarxon Sarvar O'G'Li Uroqov, Faxriddin Jaylovovich Nosirov, G'Olibjon Pardayevich Arzikulov, Zarina Amriddin Qizi Sayfutdinova

Technical science and innovation

This article explores the benefits of transitioning from traditional agricultural irrigation systems to more cost-effective alternatives powered by renewable energy sources. By integrating solar photovoltaic technology into irrigation processes, significant reductions in resource wastage, estimated at 45-50%, are achievable through the implementation of drip irrigation techniques. This results in enhanced agricultural productivity. Moreover, the utilization of solar panels in green zones mitigates surface temperature increases, contributing to a 2-5% boost in electricity production. Currently, irrigation facilities primarily rely on the main energy grid. However, transitioning to renewable energy sources decreases reliance on non-renewable fuels, reduces greenhouse gas emissions, and fosters …

Research Of The Influence Of Dust On Photovoltaic Modules, Anvarjon Mirolimov, Xalmurat Iliev

Technical science and innovation

The influence of dust concentrations on the current-voltage characteristics (voltampere characteristics) of photovoltaic modules (PVM) based on crystalline silicon in laboratory conditions. It was investigated how an uncleaned panel affects the output power. The tests were carried out in the city of Tashkent on the territory of the “National Research Institute of Renewable Energy Sources”. The objects were located co-plurally as specified in GOST R 60904-1 Photoelectric devices. Part 1. Measurement of current-voltage characteristics. Measurements of a cleaned photovoltaic module with a maximum power of 330 W and not a cleaned one of 236 W were obtained. Based on the …

Use Of Mathematical Skills For Technical Condition Assessment Of Power Autotransformers, Dilafruz Rustamjon Qizi Abdullabekova, Nurali Berdiyorovich Pirmatov

Technical science and innovation

In this paper, we review innovative approaches to assess the technical condition of autotransformers using mathematical methods. The main purpose of these methods is to increase the efficiency of diagnostics and prevent possible failures in power systems. The developed mathematical expression is based on complex data analysis, application of statistical methods and machine learning technologies. This makes it possible to achieve more accurate and earlier detection of potential problems. As a result of these innovative approaches, the possibilities for early detection and prevention of faults are significantly increased. This is important for ensuring the smooth operation of power systems and …

Quantitative Assessment And Characterization Of Tool Wear Phenomena In Advanced Manufacturing Processes, Oybek Valijonovich Tuyboyov

Technical science and innovation

This paper explores the quantitative assessment and characterization of tool wear phenomena in advanced manufacturing processes, employing a multifaceted approach encompassing traditional measurements, image processing, machine learning, and predictive modeling. The study emphasizes the intricate dynamics of tool wear and its direct impact on cutting tool performance, addressing challenges in real-time monitoring and optimization of machining operations. Traditional methods like VBmax measurement are juxtaposed with advanced techniques such as the improved conditional generative adversarial net with a high-quality optimization algorithm (CGAN-HQOA), efficient channel attention destruction and construction learning (ECADCL), and shape descriptors based on contour, moments, orientations, and texture. Artificial …

A Study On The Influence Of Cutting Parameters On Surface Roughness And Visualization Through Contour Plots And 3d Surface Profiles, Zayniddin Nosirovich Muxiddinov

Technical science and innovation

This research investigates the intricate relationship between cutting parameterscutting speed, feed rate, and depth of cut and surface roughness in machining processes. Surface roughness is a key determinant of machined surface quality, and optimizing cutting parameters is crucial for achieving superior finishes. Employing advanced visualization techniques, including contour plots and 3D surface profiles, the study offers a comprehensive exploration of surface topography dynamics. Statistical analyses and regression modeling enhance the quantitative understanding of how cutting parameters interact to shape surface roughness. The research affirms the significant influence of cutting speed, feed rate, and depth of cut, providing practical insights for …

Exploring Human Aging Proteins Based On Deep Autoencoders And K-Means Clustering, Sondos M. Hammad, Mohamed Talaat Saidahmed, Elsayed A. Sallam, Reda Elbasiony

Journal of Engineering Research

Aging significantly affects human health and the overall economy, yet understanding of the underlying molecular mechanisms remains limited. Among all human genes, almost three hundred and five have been linked to human aging. While certain subsets of these genes or specific aging-related genes have been extensively studied. There has been a lack of comprehensive examination encompassing the entire set of aging-related genes. Here, the main objective is to overcome understanding based on an innovative approach that combines the capabilities of deep learning. Particularly using One-Dimensional Deep AutoEncoder (1D-DAE). Followed by the K-means clustering technique as a means of unsupervised learning. …

Review Of The Potential Use Of Poly (Lactic-Co-Glycolic Acid) As Scaffolds In Bone Tissue Recovery, Kushendarsyah Saptaji, Asriyanti Asriyanti, Nisa Khoiriyah, Laely Muryanti, Iwan Setiawan

Makara Journal of Science

Scaffolds are used as temporary tissue in the human body to expedite healing. Biocompatible materials play a vital role in the field of tissue engineering. Therefore, they can be used to reduce human pain as soon as possible. Polymeric materials are widely used to replicate bone tissue. Poly(lactic-co-glycolic acid) (PLGA) is a potential material for bone tissue scaffolds because of its superior properties, including compatibility with the human body. Accordingly, adding hydroxyapatite and introducing different fabrication methods can enable the production of PLGA scaffolds with good abilities to help cells grow, expand, differentiate, and proliferate. The paper reviews the current …

Oral Administration Of Ph-Responsive Polymeric Nanoparticles Based On Zein And Their Therapeutic Potential On Cancer., Bruno Alejandro Valades-Aguilar, José Raúl Rangel-López, Jennifer Citlally Leos-Rivera, Moisés Armides Franco-Molina, María Cristina Rodríguez-Padilla, Diana Ginette Zárate-Triviño

Research Symposium

Background: Zein is a water-insoluble protein extracted from the endosperm of corn seeds, this polymer is an attractive matrix to encapsulate hydrophilic compounds because of its high proportion of hydrophobic amino acids, making it a potential smart delivery material for several treatments in the biopharmaceutical industry. nanoparticles have been used as drug delivery systems for the improvement of oral bioavailability; however, the strategies of nanoparticle obtention need the addition of stabilizers. in this study, a modified method to obtain zein nanoparticles was developed.

Methods: Zein nanoparticles (ZNps) were made by a thermal treatment and precipitated into ovalbumin at a ratio …

The Effect Of A Constitutive Formulation On Limb Flexion-Induced Stresses In The Human Femoropopliteal Artery: A Patient-Specific Study, Ali Ahmadi, Anastasia Desyatova

UNO Student Research and Creative Activity Fair

The Effect of a Constitutive Formulation on Limb Flexion-Induced Stresses in the Human Femoropopliteal Artery: a Patient-Specific Study

Peripheral arterial disease (PAD) involves the development of atherosclerotic lesions that restrict the flow of blood to tissues downstream. The femoropopliteal artery (FPA) experiences complex mechanical deformations during daily activities, potentially contributing to the prevalence of PAD and unfavorable treatment outcomes. These deformations generate significant intramural stresses and strains, resulting in arterial injury, disease progression, and restenosis following treatment. Computational modeling offers a way to improve the repair of the FPA; however, the accuracy of these simulations relies on the selection of …

Modes Of Fracture Of Flat Bone: Fracture Direction And Stress, Nolan Wang, Mary K. Holden, Everett Baker, Nathaniel Lerch, Nate Fitch

Seaver College Research And Scholarly Achievement Symposium

This study delineates the application of fractography to discern the multifaceted modes of fracture in flat bones, explicating the interplay between fracture directionality and stress states regarding the viscoelastic nature of bone. Despite the perceived brittleness, bone exhibits toughness, attributed to its intricate structure design and amalgamating properties of solid and viscous materials. This research elucidates the variegated fracture modes inherent to bone's dualistic nature by examining fracture surfaces and identifying fracture markings using stereoscopic microscopy. Our observations across seven bone specimens reveal predominant fracture patterns from top to bottom in six instances, with a singular deviation where the fracture …

La1-Xsrxcoo3 Perovskite Nanomaterial: Synthesis, Characterization, And Its Biomedical Application, Adhira Tippur, Anyet Shohag, Luke Franco, Ahmed Touhami, Swati Mohan, Mohammed Uddin

Research Symposium

Early cancer detection is paramount for effective treatment and potential cures. This research explores the application of perovskite materials, specifically Sr2+-doped Lanthanum Cobaltite (La1-xSrxCoO3) nanomaterials, in cancer detection, with a focus on rats as an experimental model. The ferroelectric nature of these materials, synthesized through a combination of sol-gel and molten-salt processes, was examined at varying Sr2+ doping levels (1-20 wt%). Rigorous characterization, employing X-ray diffraction and scanning electron microscopy, confirmed the uniform morphology of nano cubes, laying the foundation for subsequent investigations. The magnetic properties of the perovskite nanoparticles were probed, suggesting their potential as a diagnostic tool for …

Emotion Recognition As A Novel Indicator For Assessing Brain Health: A Machine Learning Approach, Nayarah Shabir, Parveen Lehana

Research Symposium

Background: Emotion is being referred to as a person’s mental state, since it relates to their ideas, feelings, and actions. There is a lot of evidence that health affects the emotion. Therefore, the nature of emotions ought to reveal the health of a person. The emotions are represented by facial expressions controlled by muscular motor actions. Brain health may affect the working of the muscles leading to the emotional changes extracted from the facial images.

Methods: A dataset of facial images annotated with matching emotion labels is the first step in using convolutional neural networks (CNNs) for facial …

Tracking Simulated Somatosensory Deficiencies That Affect Postural Stability Through Detrended Fluctuation Analysis, Cameron L. Steele

ELAIA

Falls are a prevalent problem among elderly populations. Falls increase the cost of healthcare, frequently cause severe injuries, and negatively affect quality of life. Lack of postural stability is a major contributing factor to falls, with postural stability defined as the correct biomechanical execution based on sensory feedback. Types of sensory feedback include vision, vestibular, proprioceptive, and somatosensory. This study focuses on the lack of postural stability in quiet standing (standing upright and still) due to somatosensory and vision deficiencies. To track these deficiencies, fifty-one subjects stood for sixty seconds on two force plates, and their center of pressure (COP) …

6d Single-Fluorogen Orientation-Localization Microscopy For Elucidating The Architecture Of Beta-Sheet Assemblies And Biomolecular Condensates, Tingting Wu, Weiyan Zhou, Jai S. Rudra, Rohit V. Pappu, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

We develop six-dimensional single-molecule orientation-localization microscopy (SMOLM) to measure the 3D positions and 3D orientations simultaneously of single fluorophores. We show how careful optimization of phase and polarization modulation components can encode phase, polarization, and angular spectrum information from each fluorescence photon into a microscope’s dipole-spread function. We used the transient binding and blinking of Nile red (NR) to characterize the helical structure of fibrils formed by designed amphipathic peptides, KFE8^L and KFE8^D, and the pathological amyloid-beta peptide Aβ42. We also deployed merocyanine 540 to uncover the interfacial architectures of biomolecular condensates.

Blow-Spun Hybrid Pcl-Peo/Hnts Scaffolds With Enhanced Biological And Mechanical Properties, Meichen Liu

Doctoral Dissertations

With the development of technology and engineering, nanotechnology has been a multidisciplinary scientific field applied in nearly all science areas, including medicine, genetics, food industry, robotics. In this respect, nanomedicine has gained increasing attention and been a useful, effective therapy for cancer diagnosis, gene transfer, and drug delivery. To design an ideal nano drug delivery system with controlled drug releasing and improved encapsulated drug’s pharmacokinetic and pharmacodynamic profiles, hydrogels and polymer composites have witnessed increased research interest during the last decades. Recently, numerous polymers have been studied to fabricate the ideal wound dressing with biocompatibility, biodegradability, porous structural, and suitable …

Development And Characterization Of Injectable, Cell-Encapsulated Chitosan-Genipin Hydrogels, Tyler R. Priddy-Arrington

Doctoral Dissertations

Over 150,000 patients undergo lower extremity amputation every year in the United States, most commonly caused by complications due to diabetes mellitus, peripheral vascular disease, and trauma. Diseased or damaged tissues that are unable to naturally repair themselves must either be fully removed or replaced, otherwise the injuries can lead to further complications such as infection or death. Tissue resection and amputation, as forms of removing damaged tissue, are not favorable to patients as they can cause pain, reduce mobility, and negatively impact quality of life. However, replacing lost or damaged tissues with donor tissues carries the risks of tissue …

Selective Targeting Of Microglia By Quantum Dots And Green Synthesis Of Metal Organic Biohybrids; Applications In Dynamic Cell And Assay Systems, Navya Uppu

Doctoral Dissertations

Neurological disorders are the leading cause of physical and cognitive disability across the globe, currently affecting approximately 15% of the worldwide population. Part of the glioma microenvironment are microglia, resident immune cells of the CNS that were thought to be involved in the pathogenesis of diverse neurodegenerative diseases. Though it remains uncertain what triggers microglial activation in these disorders, targeting and tracking microglial functions using nanotools like Quantum Dots (QDs) could help us elucidate them in such neurological diseases. This research focuses on the comparative study of different QDs formulations and their selective uptake by brain microglia in primary cultures …