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Biomedical Engineering and Bioengineering
Daniel Felix Ritchie School of Engineering and Computer Science
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Full-Text Articles in Engineering
Ex-Vivo Slaughterhouse Porcine Crystalloid-Perfused Beating Heart Via Langendorff Method, Rahiemin Talukder
Ex-Vivo Slaughterhouse Porcine Crystalloid-Perfused Beating Heart Via Langendorff Method, Rahiemin Talukder
Electronic Theses and Dissertations
The objective of this study was to resuscitate isolated beating porcine hearts obtained from slaughterhouse swine for a minimum of 1 hour with a crystalloid buffer reperfusion instead of blood via an extracorporeal Langendorff apparatus. The isolated beating heart functions outside of the body under simulated physiologic conditions. Live functional anatomy was controlled under benchtop experimental settings. Porcine hearts (26 total) were topically cooled with saline. 300mL of 25°C cardioplegia with 20KU Streptokinase was preflushed via aortic root. WIT was less than 5 minutes. 1L 4°C cardioplegia was flushed antegrade with aortic cannula (Group 1) or coronary catheterization (Group 2). …
Ultra-Wideband Radar Based Human Motion Analysis, Zhichong Zhou
Ultra-Wideband Radar Based Human Motion Analysis, Zhichong Zhou
Electronic Theses and Dissertations
This thesis proposes and investigates two techniques in ultra-wideband (UWB) radar based human motion analysis. The first one is accurate human body landmark detection using UWB radars. The detection is achieved by moving target indication (MTI) and constant false alarm rate detection (CFAR). A new CFAR detection technique is proposed, namely the out-of-band (OB) CFAR detection. In the field experiment, two RF reflective markers are attached to the wrist and elbow of one human arm for reflecting radar signals. It is demonstrated that detection of two markers are feasible and successfully achieved. And our results suggests the OB-CFAR performs better …
Anatomy, Implant Selection And Placement Influence Spine Mechanics Associated With Total Disc Replacement, Justin F.M. Hollenbeck
Anatomy, Implant Selection And Placement Influence Spine Mechanics Associated With Total Disc Replacement, Justin F.M. Hollenbeck
Electronic Theses and Dissertations
Through aging and injury, the intervertebral disc of the lumbar spine can undergo degeneration, leading to collapse of the vertebrae and low back pain, a symptom that affects half the adult population in any given year. In an effort to reduce low back pain, total disc replacement treatment removes the degenerated disc, restores natural height and lordosis of the segment, and preserves motion at the joint. Patient anatomy, implant selection, and implant placement play significant roles in a patient's outcomes after total disc replacement surgery. Thus, the objective of the work presented in this thesis was to develop a suite …
Cost-Effective Prosthetic Hand Controlled By Emg, Mohammad Yahya Almuhanna
Cost-Effective Prosthetic Hand Controlled By Emg, Mohammad Yahya Almuhanna
Electronic Theses and Dissertations
A cost-effective five-finger prosthetic hand is designed from aluminum, modeled and controlled using surface Electromyography (EMG) signals, which are obtained from the human body. Force sensors are used to control required forces needed to grasp and pick objects. A prototype hand is developed and it is experimentally tested to reproduce a wide spectrum of human hand motions. The size of the five-finger hand is similar to an adult male human hand, and it is capable of reproducing most of movements. Each finger has the same number of links as the real/human hand. Each finger also has a force sensor used …
Regional Mechanical Properties And Microstructure Of Ovine Heart Chambers, Shahnaz Javani
Regional Mechanical Properties And Microstructure Of Ovine Heart Chambers, Shahnaz Javani
Electronic Theses and Dissertations
Mechanical properties of cardiac tissue play an important role in the normal heart function. As a baseline for understanding of physiology and pathophysiology of the heart, and for development and validation of new therapies, it is crucial to first understand the mechanical behavior of the normal heart tissue. Although heart chambers have the same embryonic origin, differences in the development of mechanical properties are expected to manifest over time during the adulthood period. Therefore, the goal of this study was to determine the passive mechanical properties of all heart chambers through a paired comparison study in an ovine model. Ovine …
Multiscale Musculoskeletal Modeling Of The Lower Limb To Perform Personalized Simulations Of Movement, Alessandro Navacchia
Multiscale Musculoskeletal Modeling Of The Lower Limb To Perform Personalized Simulations Of Movement, Alessandro Navacchia
Electronic Theses and Dissertations
Computational modeling has been used for many decades to inform design and decision-making in several fields of engineering, such as aerospace, automotive, petroleum, and others. However, it still struggles to have a similar impact in fields of medicine, such as orthopaedics. Three of the challenges that have limited the use of computational modeling in the clinical practice and in product development are model validation, personalization, and realism. Validation is a challenge because several internal parameters of the human body, such as muscle forces, are not safely measurable in vivo and, consequently, a thorough comparison between model outputs …
Finite Element And Probabilistic Analysis Of Soft Tissue Structures Of The Human Lumbar Spine, Dana Joseph Coombs
Finite Element And Probabilistic Analysis Of Soft Tissue Structures Of The Human Lumbar Spine, Dana Joseph Coombs
Electronic Theses and Dissertations
Human lumbar spine mechanics are influenced by soft tissue structures. Understanding and properly modeling these structures can help determine pathology, treatment, and implant design and performance. Finite element models of the L4-L5 level of the lumbar spine are often used, which include a representation of the intervertebral disc and spinal ligaments. Validation of these models are typically based on torque rotation data from a single subject or the models use average properties reported in literature. However, experimental testing reports variation up to 40% in ligament stiffness and even greater variability for annulus fibrosis properties. Probabilistic approaches enable consideration of the …