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Spatial Control Of Magnetic Nanoparticles Integrated With Cellular Spheroids As Tissue Engineered Building Blocks, Brandon Mattix
Spatial Control Of Magnetic Nanoparticles Integrated With Cellular Spheroids As Tissue Engineered Building Blocks, Brandon Mattix
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Magnetic nanoparticles (MNPs) have been investigated in tissue engineering applications to provide in situ imaging, drug delivery, and tissue patterning, but direct and prolonged interaction between cells and MNPs can have adverse effects on cell function. Therefore, methods which reduce or limit the interaction of MNPs with cells, or utilize more biocompatible MNP-based strategies will improve upon the commonly used iron oxide MNPs. We investigated a variety of methods to improve upon the use of MNPS in tissue engineering.
Cell aggregates, or spheroids, have been used as tissue engineered building blocks that can closely mimic the native three-dimensional in vivo …