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Full-Text Articles in Engineering
Mapping The Flip Angle In Magnetic Resonance Imaging Using The Accelerated 3d Look-Locker Sequence, Trevor P. Wade
Mapping The Flip Angle In Magnetic Resonance Imaging Using The Accelerated 3d Look-Locker Sequence, Trevor P. Wade
Electronic Thesis and Dissertation Repository
In the ongoing quest to extract more information from MRI images, there has arisen a need to rapidly map the flip angle. This has been primarily driven by the shift to stronger main field strengths, which bring with them improved SNR, but also new difficulties. In particular, the radio frequency field used to excite the magnetization can no longer be assumed uniform at field strengths of 3 Tesla and above. New rapid quantitative imaging techniques, such as DESPOT1 and DESPOT2, rely on accurate knowledge of the flip angle, and while this could safely be assumed to be the prescribed value …
Alterations In Multiple Measures Of White Matter Integrity In Normal Women At High Risk For Alzheimer's Disease, Brian T. Gold, David K. Powell, Anders H. Andersen, Charles D. Smith
Alterations In Multiple Measures Of White Matter Integrity In Normal Women At High Risk For Alzheimer's Disease, Brian T. Gold, David K. Powell, Anders H. Andersen, Charles D. Smith
Neuroscience Faculty Publications
There is evidence that disruption of white matter (WM) microstructure is an early event in the course of Alzheimer's disease (AD). However, the neurobiological bases of WM microstructural declines in presymptomatic AD are unknown. In the present study we address this issue using a multimodal imaging approach to the study of presymptomatic AD. Participants were 37 high-risk (both family history of dementia and one or more APOE4 alleles) women and 20 low-risk (neither family history nor APOE4) women. Groups were matched for age, education, neuropsychological performance, and vascular factors that could affect white matter. Whole-brain analyses of diffusion tensor imaging …
Evaluation Of Upper Motor Neuron Pathology In Amyotrophic Lateral Sclerosis By Mri;Towards Identifying Noninvasive Biomarkers Of The Disease, Venkateswaran Rajagopalan
Evaluation Of Upper Motor Neuron Pathology In Amyotrophic Lateral Sclerosis By Mri;Towards Identifying Noninvasive Biomarkers Of The Disease, Venkateswaran Rajagopalan
ETD Archive
Amyotrophic lateral sclerosis (ALS) is the commonest adult motor neuron disease (MND) which causes progressive muscle paralysis and death usually within 5 years of symptom onset. As a result, only ╠â30,000 individuals in the United States are afflicted at any one time even though 5,000 or more individuals are diagnosed yearly. The diagnosis of ALS requires evidence of degeneration in upper motor neurons (UMNs) in the brain and in lower motor neurons (LMNs) that exit the brainstem and spinal cord to innervate skeletal muscles. Diagnosis can be incorrect or delayed when disease is early or atypical because non-invasive objective tests …