Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Engineering
Neomycin-Enhanced Carbodiimide Cross-Linking For Glycosaminoglycan Stability In Bioprosthetic Heart Valves, Joshua Leong
Neomycin-Enhanced Carbodiimide Cross-Linking For Glycosaminoglycan Stability In Bioprosthetic Heart Valves, Joshua Leong
All Theses
Valvular heart diseases lead to over 290,000 heart valve replacements worldwide each year, and approximately half of these involve replacement with a bioprosthetic heart valve (BHV) [1]. BHVs exhibit excellent hemocompatibility, but suffer from inadequate long-term durability with most adult implanted valves failing within 12 to 15 years after implantation [2]. Although this may be adequate for some individuals, BHV implantation may be contraindicated in younger individuals to avoid reoperation. Even in elder recipients, valve dysfunction can still cause death or reoperation that could be avoided with increased BHV durability. Therefore, investigation into methods of increasing BHV durability can not …
Characterization And Evaluation Of A Novel Tissue Engineered Aortic Heart Valve Construct, Mary Tedder
Characterization And Evaluation Of A Novel Tissue Engineered Aortic Heart Valve Construct, Mary Tedder
All Dissertations
Tissue engineering holds great promise for treatment of valvular diseases. Scaffolds for engineered heart valves must function immediately after implantation, but must also permit repopulation with autologous host cells and facilitate gradual remodeling.
Native aortic heart valves are composed of three layers, i.e. two strong external fibrous layers (ventricularis and fibrosa) separated by a central, highly hydrated spongiosa. The fibrous layers provide strength and resilience while the spongiosa layer facilitates shearing of the external layers. Our working hypothesis is that partially cross-linked collagen scaffolds that closely mimic the layered histo-architecture of the native valve would fulfill these requirements. To test …
In Vitro Evaluation Of Mechanical Heart Valve Performance Using A Novel Test Chamber In An Automated Mock Circulatory Loop, Antonio Walker
In Vitro Evaluation Of Mechanical Heart Valve Performance Using A Novel Test Chamber In An Automated Mock Circulatory Loop, Antonio Walker
Theses and Dissertations
Valvular heart disease (VHD) continues to have significant effects on many people’s lives, with numbers expected to grow tremendously over the next few years. Individuals suffering from severe valvular heart disease usually require a heart valve transplant in order to restore the native valve’s vital unidirectional flow regulation. Therefore, artificial heart valve (AHV) research is of very high importance. Previous research studies have provided substantial input in the realm of AHV design relative to durability, thrombotic and hemolytic potential, and overall functionality. However, modifications continue to be warranted due to limitations in the accuracy and time efficiency of the in …