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Use Of Short-Pulse Laser For Optical Tomography Of Tissues, Kunal Mitra, Tuan Vo-Dinh
Use Of Short-Pulse Laser For Optical Tomography Of Tissues, Kunal Mitra, Tuan Vo-Dinh
Biomedical Engineering and Sciences Faculty Publications
This paper analyzes the short pulse laser propagation through tissues for development of a time-resolved optical tomography system for detection of tumors and inhomogeneities in tissues. Traditional method for analyzing optical transport in tissues is the parabolic or diffusion approximation in which the energy flux is assumed proportional to the fluence (intensity averaged over all solid angles) gradients. The inherent drawback in this model is that it predicts infinite speed of propagation of the optical signal. In this paper accurate hyperbolic or wave nature of transient radiative transfer formulation is used to overcome such drawbacks. The transmitted and reflected intensity …
Waveguide Delivery Of X Rays For Minimally Invasive Tumor Therapy, Ronald W. Waynant, Ilko K. Ilev, Kunal Mitra
Waveguide Delivery Of X Rays For Minimally Invasive Tumor Therapy, Ronald W. Waynant, Ilko K. Ilev, Kunal Mitra
Biomedical Engineering and Sciences Faculty Publications
We are studying the potential use of x-rays, which are collected by non-imaging optics and delivered through stereotactically guided needles by hollow waveguides, for irradiation of tumors. X-rays have greater transparency in tissue than most longer optical wavelengths and may provide a more uniform dose to a tumor without harming normal tissue. Dosimetry is the key to minimal damage. We are investigating the use of fiber optics, tipped with calibrated scintillators and strategically located near the tumor, to measure the delivered dose. We are testing this procedure by using a 3 ns, variable accelerator voltage Fexitron 706 to produce approximately …