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The Effect Of Peo Ratio On Degradation, Calcification And Bone Bonding Of Peo/Pbt Copolymer (Polyactive), C. A. Van Blitterswijk, J. V.D. Brink, H. Leenders, D. Baaker
The Effect Of Peo Ratio On Degradation, Calcification And Bone Bonding Of Peo/Pbt Copolymer (Polyactive), C. A. Van Blitterswijk, J. V.D. Brink, H. Leenders, D. Baaker
Cells and Materials
In this study, we evaluated the effect of PEO/ PBT proportion on the behavior of a range of PEO/ PBT segmented copolymers (Polyactive) during subcutaneous and intrabony implantation in the rat. It was demonstrated that varying the PEO proportion affected degradation, calcification and bone-bonding. The PEO/PBT 70/30 and 60/40 showed extensive degradation after 1 year, PEO/PBT 55145 an intermediate degradation, and the 40/60 and 30170 copolymers showed little and hardly any degradation respectively. PEO content also affected the degree of calcification . PEO/PBT 70/30 showed extensive and early calcification whereas almost no calcification was seen with PEO/PBT 30170. Since calcified …
Multinucleated Giant Cells-Hydroxyapatite Interactions: A Time-Related Quantitative Study In A Rat Skull Defect, J. M. Dersot, A. Llorens, J. L. Saffar
Multinucleated Giant Cells-Hydroxyapatite Interactions: A Time-Related Quantitative Study In A Rat Skull Defect, J. M. Dersot, A. Llorens, J. L. Saffar
Cells and Materials
The implantation of calcium phosphate ceramics in the bone environment elicits the differentiation of multinucleated giant cells (MNGCs). MNGC interactions with both crushed and standard hydroxyapatite (HA, Bioapatite ®) particles (cHA and sHA) were studied in rat skull defects. Light microscopy (LM) of undemineralized material after 21 and 42 days of implantation showed that the number of particles in the defect significantly decreased (about SO%) with the two HA forms. Concomitantly, average cHA particle size increased significantly due to the elimination of the smallest particles by the MNGCs. The number of MNGCs per mm2 of defect decreased significantly between 21 …
A Comparative Study Of The Interactions Of Two Calcium Phosphates, Peo/Pbt Copolymer (Polyactive) And A Silicone Rubber With Bone And Fibrous Tissue, C. A. Van Blitterswijk, J. R. De Wijn, H. Leenders, J. V.D. Brink, S. C. Hesseling, D. Bakker
A Comparative Study Of The Interactions Of Two Calcium Phosphates, Peo/Pbt Copolymer (Polyactive) And A Silicone Rubber With Bone And Fibrous Tissue, C. A. Van Blitterswijk, J. R. De Wijn, H. Leenders, J. V.D. Brink, S. C. Hesseling, D. Bakker
Cells and Materials
In this study, hydroxyapatite, tetracalcium phosphate, HPEO/PBT 55145 copolymer, PEO/PBT 55!45 copolymer (Polyactive) and silicone rubber were implanted as dense blocks, subcutaneously and. into the tibia of rats. Biocompatibility and degradation were investigated but most attention was directed to .the bone/biomaterial interactions. None of the materials showed any significant adverse tissue reactions. With exception of the silicone rubber, all materials sho~ed bone bonding phenomena based on both morphological and mechanical evaluations. (H)PEO/PBT 55145 copolymer is the first polymer reported to be bonded by bone and thus widens the spectrum of bone bonding materials with a low modulus, degradable, elastomer in …