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Improving Cardiovascular Stent Design Using Patient-Specific Models And Shape Optimization, Timothy J. Gundert
Improving Cardiovascular Stent Design Using Patient-Specific Models And Shape Optimization, Timothy J. Gundert
Master's Theses (2009 -)
Stent geometry influences local hemodynamic alterations (i.e. the forces moving blood through the cardiovascular system) associated with adverse clinical outcomes. Computational fluid dynamics (CFD) is frequently used to quantify stent-induced hemodynamic disturbances, but previous CFD studies have relied on simplified device or vascular representations. Additionally, efforts to minimize stent-induced hemodynamic disturbances using CFD models often only compare a small number of possible stent geometries. This thesis describes methods for modeling commercial stents in patient-specific vessels along with computational techniques for determining optimal stent geometries that address the limitations of previous studies.
An efficient and robust method was developed for virtually …
Implementation And Assessment Of Hyperglycemic Conditions For The Creation Of A Diabetic Blood Vessel Mimic, Vikramaditya Mediratta
Implementation And Assessment Of Hyperglycemic Conditions For The Creation Of A Diabetic Blood Vessel Mimic, Vikramaditya Mediratta
Master's Theses
Introduction: Diabetes Mellitus is a metabolic disorder that affects a person’s ability to either produce insulin (Type I diabetes mellitus) or properly use insulin (Type II diabetes mellitus) in order to maintain adequate blood glucose levels. The most severe diabetic complications arise due to hyperglycemia – a state of extremely high blood glucose levels – such as, coronary artery disease (CAD), in which coronary stent therapy is a popular method of treatment. However, research has shown a high rate of in-stent restenosis in diabetic patients with CAD, most likely due to activation of cellular adhesion molecules on endothelial cells exposed …