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Articles 1 - 4 of 4
Full-Text Articles in Engineering
Igf-I Releasing Plga Scaffolds For Growth Plate Regeneration, Sharath Kumar Chinnakavanam Sundararaj
Igf-I Releasing Plga Scaffolds For Growth Plate Regeneration, Sharath Kumar Chinnakavanam Sundararaj
University of Kentucky Master's Theses
Growth plate is a highly organized cartilaginous tissue found at the end of long bones and is responsible for longitudinal growth of the bones. Growth plate fracture leads to retarded growth and unequal limb length, which might have a lifelong effect on a person’s physical stature. This research is a tissue engineering approach for the treatment of growth plate injury. Insulin-like growth factor I (IGF-I), which can stimulate cartilage formation, was encapsulated within PLGA microspheres that were then used to form porous scaffolds. The release profile of the IGF-I from the PLGA scaffold showed a biphasic release pattern. In vitro …
Distraction Osteogenesis In An Organ Culture Model, Bradley R. Heil
Distraction Osteogenesis In An Organ Culture Model, Bradley R. Heil
University of Kentucky Master's Theses
Distraction osteogenesis (DO) is a surgical procedure in which applied strain stimulates new bone growth; however, the underlying mechanisms by which bone cells respond to load are still uncertain. An organ culture model of DO was developed and validated by using linear distraction on the femoral shafts of 5 day old Wistar rats. Two loading regimes were utilized: distracting the bones for 2 hrs on day 1 (GRP I); distracting the bones for 2 hrs on days 1, 3, and 5 (GRP II). After 1 week in culture, the bones were compared to unloaded contralateral controls and assessed for changes. …
Correlating The Magnitude And Spatial Gradient Of Alternans, Stuart Traxel
Correlating The Magnitude And Spatial Gradient Of Alternans, Stuart Traxel
University of Kentucky Master's Theses
Electrical restitution has been shown to inaccurately predict the occurrence of alternans of action potential duration. A new method using the spatial gradient of alternans (SGA) is proposed to predict alternans and cardiac electrical stability. A simulated 1-D strand of tissue was used to compare indexes computed from restitution methods and the SGA method to changes in the amplitude of alternans using different electro-physiological alterations. The SGA method correlated better with changes in the amplitude of alternans than restitution methods for a decrease in the transient outward current (Ito) and conduction velocity. Restitution methods correlated better with changes …
Multiwall Carbon Nanotubes Alter The Thermal Profile And Antibiotic Elution Of Orthopaedic Bone Cement, Alison Carroll Tickle
Multiwall Carbon Nanotubes Alter The Thermal Profile And Antibiotic Elution Of Orthopaedic Bone Cement, Alison Carroll Tickle
University of Kentucky Master's Theses
Multiwall carbon nanotubes (MWNTs) have extraordinary mechanical and thermal transport properties. They significantly improve the static and dynamic mechanical properties of acrylic orthopaedic bone cement when added to the dry cement polymer powder. Understanding the role MWNTs play on bone cement polymerization temperatures will lead to improved mechanical integrity of the cement-bone interface in joint arthroplasties. It was determined through thermal testing that MWNTs increased the polymerization time of the methylmethacrylate by 45-460% and decreased the peak exothermic temperature of bone cement with and without antibiotics. The flow of heat produced during polymerizing cement was reduced 25-85% with the addition …