Engineering Commons^™

Design Of Three-Dimensional Axon Stretch Growth Device, Fayekah Assanah

Theses

Spinal Cord Injury (SCI) causes destruction and degeneration of axons in the white matter of the spinal cord, resulting in functional loss and paralysis. A successful treatment of SCI requires axons to regenerate across damaged regions. Current studies focus on identifying mechanisms to promote axon regeneration in lesions and have yet to be successful in preventing nerve degeneration due to scar tissue formation. Establishing axonal bridges over long distances of SCI lesions remains a challenge, resulting in poor functional recovery. Instead of relying on promoting axon regeneration into lesions, Pfister et al. has developed a transplantable nervous tissue construct spanned …