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Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang
Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang
McKelvey School of Engineering Theses & Dissertations
Antibody-antigen recognition enables antibody-conjugated nanostructures to serve as plasmonic biosensors with tunable specificity. However due to the instability of antibodies, these biosensors are susceptible to changes in the environment such as heat and aridity, leading to constraints on the transportation and handling of these sensors. Here we establish a method using a metal-organic framework crystal to preserve biosensor activity under severe environmental conditions, including exposure to high temperatures, an organic solvent and a proteolytic agent. After zeolitic imidazolate framework-8 (ZIF-8) crystals formed for 12 hours on a biosensor of gold nanorods conjugated with a model antibody, rabbit IgG, 80% of …
Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou
Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou
McKelvey School of Engineering Theses & Dissertations
Stroke is the most common cause of long-term severe disability and the motor system that is most commonly affected in stroke. One of the mechanisms that underlies recovery of motor deficits is reorganization or remapping of functional representations around the motor cortex. This mechanism has been shown in monkeys, but results in human subjects have been variable. In this thesis, I used a database that includes longitudinal behavioral and multimodal imaging data in both stroke patients and healthy controls for two research projects. Firstly, I improved an automatic lesion segmentation method to aid in the identification of the location and …