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Time Evolution Of Ecog Network Connectivity In Patients With Refractory Epilepsy, Michael J. Selesko
Time Evolution Of Ecog Network Connectivity In Patients With Refractory Epilepsy, Michael J. Selesko
Masters Theses
Epilepsy is a common neurological disorder that causes recurrent, unprovoked seizures. Focal, refractory epilepsy is characterized by seizures that start in a specific area in the brain and do not respond to antiepileptic medication. This study was conducted to characterize the connectivity of the focal brain region where seizures originate, known as the epileptogenic zone. Connectivity was measured from electrocorticogram (ECoG) recordings, during seizure events, using information theoretic measures mutual information (MI) and (TE). MI is the amount of information shared between two discrete random variables. TE is the directed information transfer between two discrete random variables. MI provides information …
Identification Of The Seizure Onset Zone By Auto-Regressive Model Residual Modulation Applied To Intracranial Eeg And Its Correlation To Channels With High Preponderances Of Detected Hfos, Allison L. Rogutich
Identification Of The Seizure Onset Zone By Auto-Regressive Model Residual Modulation Applied To Intracranial Eeg And Its Correlation To Channels With High Preponderances Of Detected Hfos, Allison L. Rogutich
Masters Theses
The objective of this thesis was to examine the ability of the Autoregressive Model Residual Modulation (ARRm) method to identify the Seizure Onset Zone (SOZ) in intracranial electroencephalogram (iEEG) of patients with refractory epilepsy. Patients who have not become seizure free after multiple trials of antiepileptic drugs (AEDs) may seek treatment through epilepsy surgery. Cortical electrodes are implanted directly on the cerebral cortex, then iEEG is collected. A specialized neurologist reviews the iEEG, then in consultation with the neurosurgeon, the SOZ is determined and areas of the brain may be chosen for resection. The success rate of epilepsy surgery varies, …